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Endocannabinoid System Regulation in Pyometra-Affected and Healthy Canine Uteri

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By Isil Unaldi, Anıl Gürkan Aksu, Volkan Ferahoğlu, Fatih Büyükbudak
| preprints.org
Submitted: 08 September 2025 Posted: 09 September 2025 You are already at the latest version Pyometra is a frequent and life-threatening reproductive disorder in bitches, characterized by profound immune and inflammatory responses within the uterus. The endocannabinoid system (eCS) is a key modulator of immune regulation, tissue homeostasis, and inflammation; however, its role in canine uterine physiology and pathology remains unexplored.
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