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Ava Jarvis

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Articles

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease - Ijezie - Brain Pathology - Wiley Online Library

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By Emmanuel C. Ijezie, Michael Miller, Céline SC Hardy, Ava Jarvis
| Wiley Online Library Verified
1 INTRODUCTION Alzheimer's disease (AD) is a neurological disorder that is characterized by progressive neurodegeneration and accumulation of amyloid-ß (Aβ) plaques and aggregated Tau proteins [1]. AD is currently the leading cause of dementia in the world. The economic impact of AD progression on the United States healthcare system is projected to be in excess of $360 billion in 2024, and this number is expected to continue rising [2].
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HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease

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By Emmanuel C. Ijezie, Michael Miller, Céline SC Hardy, Ava Jarvis
| BioRxiv
Abstract INTRODUCTION: Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer's Disease (AD) in neurons. One key marker of AD is the hyperphosphorylation of Tau, accompanied by altered levels of Tau isoforms.
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Adaptable, turn-on maturation (ATOM) fluorescent biosensors for multiplexed detection in cells - Nature Methods

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By Spencer B. Procopio, Ava Jarvis, Anna John
| Nature Verified
Abstract A grand challenge in biosensor design is to develop a single-molecule, fluorescent protein-based platform that can be easily adapted to recognize targets of choice. Here, we created a family of adaptable, turn-on maturation (ATOM) biosensors consisting of a monobody (circularly permuted at one of two positions) or a nanobody (circularly permuted at one of three positions) inserted into a fluorescent protein at one of three surface loops.
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