Balvinder Kaur Sapra on Muck Rack

Balvinder Kaur Sapra

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Retarded DNA DSB repair kinetics and augmented radiation sensitivity in Wiskott Aldrich syndrome patients

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By Ranjana Pathak, Rajesh Kumar Chaurasia, Pallavi B. Gaikwad, Umair Ahmed Bargir, Manisha Madkaikar, Anjana Goel, Nagesh N Bhat, Arshad Khan, Balvinder Kaur Sapra, Kapil B. Shirsath
| Nature
Abstract Wiskott–Aldrich Syndrome (WAS), a rare X-linked disorder, features microthrombocytopenia, eczema, immunodeficiency, and elevated malignancy risk due to genomic instability. While prior studies noted DNA repair deficits, the kinetics of ionizing radiation-induced DSB repair in WAS patients remain unclear. This study aimed to characterize DSB repair dynamics and radiation sensitivity in WAS lymphocytes using γH2AX and 53BP1 markers.
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