Beihong Ji

Special Issue Published as part of Journal of Chemical Information and Modeling special issue “Chemical Compound Space Exploration by Multiscale High-Throughput Screening and Machine Learning”. Introduction Click to copy section linkSection link copied! Nonsupervised molecular generation has become a cornerstone of modern computational drug discovery, offering innovative approaches for designing novel compounds with the desired properties.

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Diamorphine hydrochloride is primarily used intranasally to manage breakthrough pain in pediatric patients, offering great advantages over injected administration. However, current dosing practices are largely based on clinical expertise due to limited understanding of its pharmacokinetics in children. WHAT QUESTION DID THIS STUDY ADDRESS?

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202411334-sup-0001-SuppMat.docx27.7 MB Supporting Information References 1, , Transl. Lung Cancer Res. 2016, 5, 288. 2a) , , J. Clin. Oncol. 2008, 26, 2883; b) , , , Front. Biosci. 2011, 16, 1927. 3, , , Biomed. Pharmacother. 2013, 67, 669. 4, , , , Semin. Cancer Biol. 2015, 31, 16. 5, , , , , , , , Nat. Rev. Clin. Oncol. 2015, 12, 445. 6, , , , , , , , , , , Signal Transduction Targeted Ther. 2020, 5, 8.