AbstractX-chromosome inactivation triggers fusion of A/B compartments to inactive X (Xi)-specific structures known as S1 and S2 compartments. SMCHD1 then merges S1/S2s to form the Xi super-structure. Here, we ask how S1/S2 compartments form and reveal that Xist RNA drives their formation via recruitment of Polycomb repressive complex 1 (PRC1). Ablating Smchd1 in post-XCI cells unveils S1/S2 structures. Loss of SMCHD1 leads to trapping Xist in the S1 compartment, impairing RNA spreading into S2.
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. ORIGINAL ARTICLE Meeting the need or falling in line? The effect of laissez‐faire formal leaders on informal leadership Wu WeiCorresponding Author E-mail address: email@example.com Economics and Management School, Wuhan University, Hubei, China Correspondence Wu Wei, Economics and Management School, Wuhan University, Luojia Hill, Wuhan, 430072, Hubei, China.