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Articles by I. Rybak
Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing
Clinical Trial R.K. Sivamani Corresponding Author E-mail address: raja.sivamani.md@gmail.com Department of Dermatology, University of California – Davis, Sacramento, CA, U.S.A. Department of Biological Sciences, California State University, Sacramento, CA, U.S.A. Correspondence Raja K. Sivamani. E‐mail: raja.sivamani.md@gmail.com Search for more papers by this author PDF PDF Share
British Journal of Dermatology
Summary 补骨脂酚主要存在于印度植物“补骨脂”(Psoralea corylifolia [babchi]) 的种子中,最近的研究表明,补骨脂酚具有多种抗氧化和抗炎特性。本研究由来自美国加利福尼亚、密歇根州、佛罗里达州和宾夕法尼亚州几所大学的研究人员开展,旨在对补骨脂酚与常用抗衰老物质“视黄醇”进行功效和副作用比较。44 名志愿者被要求在面部皮肤上每天两次涂抹 0.5% 的补骨脂酚乳膏或者每天一次涂抹 0.5% 的视黄醇乳膏,连续涂抹 12 周。此前的研究表明,0.5% 视黄醇可有效预防和消除皮肤衰老征兆,但会引起刺痛、起皮、发红等副作用。一台面部照相和分析系统用来在本研究第 0、4、8 和 12 周拍摄并分析高分辨率照片。患者也回答了有关副作用的问题。研究访视期间,一名皮肤病医生对色素沉着(皮肤着色)和发红体征进行了分级。为了避免发生偏倚,这名皮肤病医生对每位参加者当时使用哪种治疗并不知情。本研究发现,补骨脂酚和视黄醇都会显著缩小皱纹表面积并减少色素沉着过度,两种化合物之间不存在统计学意义上的差别。但视黄醇使用者报告起皮和皮肤刺痛的频率更高。上述结果在 12...
Assessment of topical bakuchiol and retinol for facial photoageing
Summary Bakuchiol is found mainly in the seeds of the Indian plant Psoralea corylifolia (babchi) and has recently been shown to have a number of antioxidant and anti‐inflammatory properties. The goal of this study, by researchers from universities in California, Michigan, Florida and Pennsylvania in the US, was to compare the efficacy and side effects of bakuchiol with the commonly‐used anti‐ageing ingredient retinol.
Assessment of topical bakuchiol and retinol for facial photoageing
Plain Language Summary Assessment of topical bakuchiol and retinol for facial photoageing PDF PDF Share Summary Bakuchiol is found mainly in the seeds of the Indian plant Psoralea corylifolia (babchi) and has recently been shown to have a number of antioxidant and anti‐inflammatory properties.
Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoaging
Bakuchiol is a phytochemical that has demonstrated cutaneous anti‐aging effects when applied topically. Early studies have suggested that bakuchiol is a functional analog of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side effects.
Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing
For centuries, botanicals were the fundamental basis of treatment for various ailments.1 Even now, many well‐known medications are derived from plants.
Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing
Summary Background Bakuchiol is a phytochemical that has demonstrated cutaneous antiageing effects when applied topically. Early studies have suggested that bakuchiol is a functional analogue of topical retinoids, as both compounds have been shown to induce similar gene expression in the skin and lead to improvement of cutaneous photodamage. No in vivo studies have compared the two compounds for efficacy and side‐effects.
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