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Kevin Bruce

As seen in: Medium, Nature, BioRxiv, Stem Cell Reports, On3, WeAreSC, Cell & Gene Therapy Insights, Virden Empire-Advance
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Articles

Charting the translational pathway: ISSCR best practices for the development of PSC-derived therapies

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By Ricardo Baptista, Chris Barry, Kevin Bruce, Melissa Carpenter, Lila Collins, Elizabeth Csaszar, Kate Fynes, Michela Gabaldo, Jie Hao, Derek Hei, Claire Henchcliffe, Ana Hidalgo-Simon, Jennifer Hollands, Deborah Hursh, Shawna Jackman, Kilian Kelly, Jung-Hyun Kim, Hyunyoung G. Kim, Masahiro Kino-oka, Uma Lakshmipathy, Tyler Lamb, Stanley E Lazic, Jeanne Loring, Tenneille Ludwig, Indumathi Mariappan, Christelle Monville, Andras Nagy Verified, Hideyuki Okano, Graziella Pellegrini, John Rasko, Dhruv Sareen, Yoji Sato, Glyn Stacey, Clive Svendsen, Mark Tomishima, Alan Trounson, Sowmya Viswanathan, Shuyan Wang, Kirsty Wydenbach, Alex Zhang, Claudia Zylberberg, Kapil Bharti, Jaqueline Barry, Elsa Abranches, Catharina Brandsten, Joy Cavagnaro, Jennifer Dashnau, Denise de Villa, Tamar Harel-Adar, Joanne C. Mountford, Annelie Persson, Kendra Prutton, Anat Shnaiderman, Jack T. Mosher
| Stem Cell Reports Verified
PerspectiveOnline now102784Open access 1Cell and Gene Therapy Catapult, Edinburgh and London, UK 2ViSync Technologies, Oeiras, Portugal 3SmartCella, Stockholm, Sweden 4Evanston, IL ISSCR, USA 5Takara Bio Europe, Gothenburg, Sweden 6RoslinCT, Edinburgh, UK 7Carpenter Consulting Corporation, Seattle, WA, USA 8Access Bio, Boyce, VA, USA 9California Institute for Regenerative Medicine, South San Francisco, CA, USA 10University Health Network, Toronto, ON, Canada 11Century Therapeutics,...
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Pneumococcal S protein coordinates cell wall modification and repair to resist host antimicrobials - Nature Microbiology

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By Jessica Burnier, Kevin Bruce, Ho-Ching Tiffany Tsui, Johann Mignolet, Victor Nizet
| Nature Verified
Abstract S protein is conserved among streptococci and contributes to group A Streptococcus virulence, but the mechanisms involved are unclear. Here we used genetic, biochemical, single-molecule, in vitro and in vivo analyses to show that S protein is crucial for resistance against host-derived antimicrobials by coordinating cell wall modification and repair.
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Regulation of the essential peptidoglycan hydrolytic complex FtsEX-PcsB during Streptococcus pneumoniae cell division

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By Nicholas Briggs, Kevin Bruce, Souvik Naskar, Stefano Camaione
| BioRxiv
Abstract In the human commensal Gram-positive bacterial pathogen Streptococcus pneumoniae, the essential extracellular cell-division-associated peptidoglycan (PG) hydrolase PcsB interacts directly with the cytoplasmic-membrane-bound complex between FtsE and FtsX (1-3). PcsB contains a cysteine, histidine-dependent amidohydrolase/peptidase (CHAP) domain responsible for PG hydrolysis, as well as a coiled-coil domain required for interaction with FtsEX (1,4).
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