Volume 93 Issue 18 | pp. 18-19Issue Date: May 4, 2015Michael Sofia Looks To Strike Gold TwiceAfter discovering a game-changing pill for hepatitis C, medicinal chemist turns his attention to hepatitis B
The chances of any one chemist discovering a drug that works—a molecule that is safe and improves people’s lives in a meaningful way—are small. The chances of discovering an actual cure? Minuscule. Medicinal chemist Michael Sofia has managed to beat the odds.
The biotech firm Torque has launched with $25 million in funding from Flagship Pioneering with the goal of making cellular therapies more effective across a broader range of tumors. To do so, the Cambridge, Mass.-based company is arming immune cells with small molecules, antibodies, or small signaling proteins called cytokines. Torque joins a legion of companies tinkering with immune cells so they can find and attack cancer cells.
In a deal worth up to $1.5 billion, Bayer and Loxo Oncology will jointly develop two Loxo drug candidates, larotrectinib and LOXO-195, for treating cancers caused by a rare genetic mutation. Loxo gets $400 million upfront; the remainder of the money is tied to the approval and sale of the two compounds. Larotrectinib and the follow-on compound LOXO-195 both block TRK gene fusions, a chromosomal mismatch found in less than 1% of cancers.
Muck Rack makes it simple to find people, tweets, or articles that mention any name, keyword, company, hashtag etc. We've compiled this guide to help you make the most of your search.
Selecting a term
Start searching tweets, articles from media outlets, articles mentioned in tweets, journalists'
names, titles and bios with some suggested searches:
Companies or Topics (e.g. iPhone, Microsoft)
Phrases (e.g. "cloud computing") — use quotes to keep the terms together
Twitter handles (e.g. @username) — returns those who have mentioned or replied to
Names (e.g. "David Pogue")
Hashtags (e.g. #sxsw, #london2012)
Bio details (e.g. vegan, Olympics, father)
Muck Rack's Advanced Search allows for many boolean operators.
Find results that mention multiple specified terms, use AND or
+. For example, ensure each result contains both Elon Musk and Mark Zuckerberg by
searching Musk AND Zuckerberg or Musk + Zuckerberg.
Use the operators OR or , to broaden your search when you'd like either of
multiple terms to appear in results. (This is the default behavior of our search when no operators
are used). For example, results will contain either cake or cookie by searching cake OR cookie or cake,cookie
Use NOT or - to subtract results from your search. For
example, searching Disney will yield results about the Walt Disney Company as well as Walt Disney
World Resort. To exclude mentions of Disney World, search for Disney -World or Disney
When using one of these operators with a phrase, enclose it in quotation marks. For example, you can
find results about smartphones excluding Apple's iPhone 4S by searching smartphone -"iPhone
Exact case matching or punctuation
If you're searching for a brand name or keyword that relies on specific punctuation marks or capitalization, you can
find results that match your exact query by adding matchcase: before the keyword you're searching for, like matchcase:E*TRADE .
Use parentheses to separate multiple
boolean phrases. For example, to find journalists talking about having fun in Disney World or
Disneyland, search for ("disney world" OR disneyland) AND fun.
An asterisk can be used to search for any variation of a root word truncated by the asterisk. For example, searching for admin* will return results for administrator, administration, administer, administered, etc.
A near operator is an AND operator where you can control the distance between the words. You can vary the distance the near operation uses by adding a forward slash and number (between 0-99) such as strawberries NEAR/10 "whipped cream", which means the strawberries must exist within 10 words of "whipped cream".