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A pseudouridine synthase shapes tRNA structural dynamics through both catalysis and remodeling
Abstract Transfer RNA has long served as an exemplar of a thermodynamically stable, structured RNA. Yet it undergoes significant structural changes upon binding and catalysis by diverse modification enzymes. We leveraged optical binding assays and single-molecule FRET to observe tRNA structural dynamics before and upon interaction with the conserved pseudouridine synthase Pus4/TruB.
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Margaret L
Contact Margaret L, search articles and posts on X, monitor coverage, and track replies from one place.
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