Joint pain can be caused by several different things, some more serious than others. If you injure yourself, you can experience joint pain. If you have an autoimmune disease, you can experience joint pain. Joint pain can occur anywhere in the body that is a joint. This means you can experience big toe joint pain, knee pain, wrist pain, and knee pain. For some, joint pain is so severe it negatively impacts their day-to-day life. From the moment a person wakes up, they can suffer from joint pain.