Novartis, a global health care company based in Switzerland, is closing its Broomfield manufacturing plant at 2555 W. Midway Blvd. Approximately 450 jobs will be affected as a result of the closure, Novartis spokeswoman Sofina Mirza-Reid said this morning. It is unclear when the business will shut down. Sandoz Inc., of Dallas, is listed as the property owner, according to Broomfield records. The property was valued at $13.5 million at its last assessment in 2017.