In this study we described a new function of TM in VSMCs. We showed that TM enhances cell adhesion, spreading, and migration of VSMCs. Moreover, we provide evidence showing that the CS moiety at the serine/threonine-rich domain of TM mediates these functions. Smooth muscle cell migration is an integral part of vascular development, atherogenesis, and injury-induced vascular remodeling [1, 31]. Migration is a multistep process which involves cell protrusion, adhesion, spreading, and contraction .