Napat Laoaroon

Abstract Hemoglobin H (Hb H) disease is a prevalent hereditary hemolytic anemia worldwide. Clinical severity varies by genotype, particularly between deletional and non-deletional forms, as well as the presence of co-inherited Hb E. However, disease-related complications remain underreported. We analyzed a Thai multicenter registry of 1,298 patients with Hb H disease to evaluate disease-related complications and risk factors.

Abstract Neonatal jaundice is most commonly caused by blood group incompatibility but may also result from hereditary elliptocytosis (HE) associated with heterozygous SPTB mutations. A retrospective descriptive study was conducted among 1,584 neonates presenting with jaundice over a 3-year period. Seventy-six neonates (4.8%) were diagnosed with HE, all carrying heterozygous SPTB mutations (Providence variant, n = 67; Buffalo variant, n = 9). Five had coexisting hemoglobinopathies.

CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description bjh19869-sup-0001-AppendixS1.docxWord 2007 document , 14.8 KB Appendix S1. bjh19869-sup-0002-AppendixS2.docxWord 2007 document , 14.7 KB Appendix S2. REFERENCES 1, . Problems of thalassemia in Thailand. ICMR Ann. 1988; 8: 29–33. 2, , , , , , et al. Estimating the burden of α-thalassaemia in Thailand using a comprehensive prevalence database for Southeast Asia. elife. 2019; 8:e40580.