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Sévan Stroh on Muck Rack

Sévan Stroh

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Articles

Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity

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By Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino
| MDPI
1. Introduction Hypertension is strongly associated with an increased risk of cardiovascular events, stroke, and kidney disease [1]. Blood pressure depends on salt balance, although the salt-induced blood pressure response varies within a population [2]. Increased Na+-transport via the renal epithelial sodium channel (ENaC) was proposed to be a common phenomenon in salt-dependent forms of hypertension [3]. Trypsin-like proteases were first identified as new autocrine regulators of ENaC in vitro [4].
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