Warissara Wongkham on Muck Rack

Warissara Wongkham

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Synergistic anticancer effects of peanut hairy root culture crude extract in combination with gemcitabine against cholangiocarcinoma

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By Worasak Kaewkong, Sarawut Kumphune, Suchada Phimsen, Warissara Wongkham, Piyathida Wongkham, Apinun Limmongkon
| Nature
Abstract Cholangiocarcinoma (CCA) is a highly aggressive malignancy with limited treatment options and frequent chemoresistance. Peanut hairy root culture crude extract (PCE) has previously demonstrated selective cytotoxicity toward CCA cells. Here, we investigated the combinatorial effects of PCE with standard chemotherapeutic agents on CCA cell lines. In KKU-213 A cells, PCE exhibited antagonistic and additive interactions with gemcitabine (Gem) and 5-fluorouracil (5-FU), respectively.
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