Frontiers | Association between platelet-to-albumin ratio and total spine bone mineral density in older adults with thoracolumbar fragility fractures: a retrospective cross-sectional study

1 Introduction Societal progression has fueled a global demographic shift toward aging populations, concurrently driving a steady increase in the incidence of thoracolumbar fragility fractures (TLFFs)—a condition tightly linked to osteoporosis and a growing concern in orthopedic medicine (1, 2). As a devastating sequela of osteoporosis, TLFFs are distinguished not only by their high prevalence but also by the heavy burdens of mortality and long-term disability they impose (3).