ABSTRACT Objective To examine the association between somatic syndromes and long COVID through a pre-registered cross-sectional survey. Methods United States adults (N = 2872) participated in an online survey detailing health history, including somatic syndrome and long COVID status. Multivariable logistic regression models were used to examine pre-COVID-19 somatic syndromes as a predictor of long COVID, as well as long COVID as a predictor of post-COVID-19 somatic syndromes.