Honokiol relieves hippocampal neuronal damage in Alzheimer's disease by activating the SIRT3‐mediated mitochondrial autophagy

1 INTRODUCTION Alzheimer's disease (AD), a common neurodegenerative disease, is characterized by progressive memory loss and cognitive and language impairment.1 In general, AD initiation and progression occur via amyloid-β (Aβ) aggregation in neurons, and the removal of these neurotoxic Aβ aggregates has been proposed as an attractive strategy for treating AD.2, 3 AD usually develops in people over the age of 60 and is responsible for more than 90% of all dementia cases worldwide.4 AD...