Dual MAPK Inhibition Triggers Pro-inflammatory Signals and Sensitizes BRAF V600E Glioma to T Cell-Mediated Checkpoint Therapy

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By Yao Xing, Stefan Grossauer, Jong-Whi Park, Emon Nasajpour
| biorxiv.org
Abstract BRAF V600E pediatric low-grade gliomas frequently transform into high-grade gliomas (HGG) and poorly respond to chemotherapy, resulting in high mortality. Although combined BRAF and MEK inhibition (BRAFi+MEKi) outperforms chemotherapy, ~70% of BRAF V600E HGG patients are therapy resistant and undergo unbridled tumor progression.
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