Shunmei Chen, Cihan Ruan, Yutong Guo, Jia Chang, Haohao Yan, Liang Chen, Yongzhong Duan, Guangyou Duan, Jinlong Bei, Xin Li, Shan Gao Abstract Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), its genetic and geographical origins remain unclear, resulting in suspicions about its natural origin.