Clozapine is often prescribed to manage treatment-resistant schizophrenia,1,2 defined as an inadequate response to at least 2 trials of antipsychotic medication of adequate dose and duration.3 Despite its clinical benefits, clozapine has potentially life-threatening side effects, eg, hematologic, metabolic, and cardiac effects.4 Impairment of gastrointestinal motility is also common, with an estimated occurrence of 14%.5 Gastrointestinal hypomotility can lead to paralytic ileus, obstruction,...