Abstract Glia serve as double-edged swords to modulate neuropathology in Parkinson's disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating alpha-synuclein (alpha-syn) inclusions, remains elusive. Here we present evidence that dAuxilin (dAux), the Drosophila homolog of the PD risk factor Cyclin G-associated kinase (GAK), regulates the lysosomal degradation of alpha-syn in glia.