CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl. 2022; 12(1): 7-11. doi:10.1016/j.kisu.2021.11.003 2. Mechanisms of renal fibrosis. Annu Rev Physiol. 2018; 80: 309-326. doi:10.1146/annurev-physiol-022516-034227 3, , , . Dihydroquercetin protects against renal fibrosis by activating the Nrf2 pathway. Phytomedicine. 2020; 69:153185. doi:10.1016/j.phymed.2020.153185 4, , .