1. Introduction Renal cell carcinoma (RCC) affects more than 400,000 individuals per year worldwide [1]. Clear cell RCC (ccRCC) is the most common histotype of RCC, making up approximately 70% of the total cases [2]. The widespread use of cancer screening imaging increased the detection of incidental small renal masses (≤4 cm), a non-negligible rate of which (ranging from 7 to 33%) is benign lesions, such as renal oncocytoma (RO) [3].