Keywords Sarcomas Quality of life Global health Systemic therapy Evidence before this study We searched PubMed for studies on health-related quality of life (HRQoL) in advanced soft tissue sarcoma (STS) patients receiving first-line palliative chemotherapy, using terms including “advanced soft tissue sarcoma”, “quality of life” and “chemotherapy”. The search included all languages and covered studies published from database inception to February 2025.