Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery - Nature Cardiovascular Research

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By Leili Jafari, Dimitri Grün, Prakash Chelladurai, Stefan Guenther, Carsten Kuenne, Jochen Wilhelm, Baktybek Kojonazarov, Ralph T Schermuly, Stefan Guth, Edda Spiekerkoetter, Werner Seeger, Christoph Liebetrau, Alicia M. Späth
| Nature
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) leads to progressive right ventricular (RV) dysfunction. Pulmonary endarterectomy (PEA) is an established treatment for these patients; however, the molecular mechanisms underlying RV remodeling and recovery remain poorly understood. Here we show that RNA sequencing and histological analysis of RV free wall and septal biopsies from patients with CTEPH reveal extracellular matrix enrichment and cytoskeletal remodeling before PEA.
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