The lateral habenula (LHb) is an evolutionarily conserved epithalamus nucleus, which receives a wide range of inputs from the limbic forebrain regions to basal ganglia structures and in turn directly or indirectly innervates midbrain monoaminergic centers.1,2,3,4 The LHb integrates environmental cues and experience-dependent information and thus accordingly regulates motivational processes,5,6 memory,7,8,9 and social behaviors.10 Dysfunction of the LHb is causally involved in the...