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| Scope | National |
|---|---|
| Language | English |
| Country | United Kingdom |
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| Accepts contributed content | Yes |
Recent Articles
Search ArticlesComputational insights into the regulatory role and functional significance of NOTCH1 intronic SNP rs3124599 and its link to NPC
Highlights • SNP rs3124599 may regulate NOTCH1 expression via chromatin and TF binding. • FunSeq2 predicts rs3124599 as deleterious; cross-validation supports impact. • eQTL analysis shows rs3124599 affects multiple genes in a tissue-specific manner. • Allele A is more frequent in East Asians, suggesting population-specific effects. • Experimental validation is needed to confirm role of rs3124599 in NPC susceptibility.
Bloodstream infections by zoonotic Capnocytophaga species: A review of reported cases, 2016-2025
Published by: Elsevier Published by Show more Bloodstream infections by zoonotic Capnocytophaga species: A review of reported cases, 2016-2025 Author links open overlay panelSofia Maraki a † , Viktoria Eirini Mavromanolaki b †, Evangelia Iliaki-Giannakoudaki a, Anna Kasimati a Show more Highlights • Zoonotic Capnocytophaga species are Gram-negative commensal bacteria in the oral cavities of dogs and cats, transmitted to humans via bites, scratches, or close contact.
Commentary Weight-loss-independent actions of GLP-1 medicines
Cell Metabolism Volume 38, Issue 8, 4 August 2026, Pages 1535-1539 Weight-loss-independent actions of GLP-1 medicines Author links open overlay panelMaria J. Gonzalez-Rellan 1, Daniel J. Drucker 1 Show more The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to improve cardiovascular, renal, hepatic, musculoskeletal, and organismal health.
Early-life exposure to plastics is associated with health parameters and biomarkers in southern giant petrels
Early-life exposure to plastics is associated with health parameters and biomarkers in southern giant petrels Author links open overlay panelLuciana Gallo a b, Flavio Quintana a, Andrés M. Attademo c, Marcela M. Uhart d Show more Highlights • Most petrel chicks were fed plastic by parents during growth. • Plastic ingestion was associated with nutrition, metabolism, and immunity. • Plastic-health indicator associations weakened by fledging.
Synthesis and antimalarial activity of novel C30-aminated betulin derivatives
Synthesis and antimalarial activity of novel C30-aminated betulin derivatives Author links open overlay panelChristopher Bérubé a b c d, Catherine Bergeron a b, Dominic Gagnon b f, Mathieu Gagné-Boulet a b, Sébastien Fortin a b, Simon Côté e, Fernando Albericio c d, Dave Richard b f, Eric Biron a b Show more Highlights • Derivatization of betulin at the C30 position was achieved in only 3 three steps. • A novel series of C30-aminated betulin derivatives was synthesized in good yields.
In silico structure-based design of superior DYRK1A enzyme inhibitors
Highlights • DYRK1A identified as a multifunctional kinase linked to multiple diseases. • Robust 3D-QSAR model developed for rational DYRK1A inhibitor design. • 138,651 compounds generated and prioritized via comprehensive in silico screening. • Top candidates showed strong affinity and stability in MD and MM(PB/GB)SA. • QTAIM and IGMH analyses confirmed key interactions of proposed compounds.
Improved protocol for isolation and characterization of human thymic epithelial cells
Published by: Elsevier Published by Show more Improved protocol for isolation and characterization of human thymic epithelial cells Author links open overlay panelNaoko Matsui a , Hiroyuki Kondo b, Kazuhiro Maejima c, Yosuke Matsushita d e, Yohei Yamamoto f, Eri Otsu g, Muhammad Myn Uddin g, Mikio Sugano h, Takashi Kitaichi h, Toyomasa Katagiri d e, Hiroki Hata h, Kazuya Kondo i, Yuishin Izumi a, Yousuke Takahama j, Hidewaki Nakagawa c, Izumi Ohigashi g k Show more Abstract Thymic epithelial...
Full Length Article OPtimal TIming for Reperfusion in Acute Pulmonary Embolism: Rationale and design of the OPTIRAPE registry
Thrombosis Research Available online 1 September 2026, 109824 OPtimal TIming for Reperfusion in Acute Pulmonary Embolism: Rationale and design of the OPTIRAPE registry Author links open overlay panelMarco Zuin a b c d , Cecilia Becattini e, Alice Sacco f, Guido Tavazzi g, Claudia Colombo f, Rosalinda Madonna h, Maria Cristina Vedovati e, Chiara Dalla Valle i, Catia De Rosa j, Stefano Ghio g, Leonardo De Luca g, Pier Luigi Temporelli k, Giuseppe Musumeci j, Rigatelli Gianluca d, Fabrizio Oliva...
A Magnetic Copper-Based Metal–Organic Gel-derived Aerogel for Spin-Assisted Dispersive Micro-Solid Phase Extraction of Trace Organophosphorus Pesticide Residues in Plant-based Milk Alternatives Followed By LC–MS/MS
Highlights • A magnetic copper-based MOG-derived aerogel was fabricated as an efficient sorbent. • A custom spin-assisted magnetic extraction device was proposed for dispersive µ-SPE. • The assessment of OPPs in plant-based milk alternatives was conducted for the first time.
Development of a 96-well murine whole blood intracellular cytokine staining (ICS) assay for preclinical tuberculosis immune monitoring
Highlights • Developed a 96-well murine whole blood ICS workflow using small-volume blood samples. • Defined key blood handling and red blood cell processing variables that limit cytokine detection. • Heparinized collection and pre-culture RBC lysis enable mitogen-driven cytokine responses. • Broad M. tb epitope stimulation reveals infection-driven antigen-specific T cell responses in blood. • Parallel CD44-based and total T cell gating analyses identify assay sensitivity limits.