Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation | Nature Metabolism

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By Alva M. Casey, Dylan Ryan, Hiran A. Prag, Keira Turner, Anja V. Gruszczyk, Jan Lj. Miljkovic, Richard Hartley, Christian Frezza, Julien Prudent, Joyce Valadares
| Nature
Abstract Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents and redox signals; however, the mechanism of LPS-induced mitochondrial superoxide generation is unknown. Here we show that LPS-stimulated bone-marrow-derived macrophages produce superoxide by reverse electron transport (RET) at complex I of the electron transport chain.
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