Nature Reviews Genetics

In this Journal Club, Hodkinson and Larschan recall a 2002 paper by Meller and Rattner that used the power of Drosophila genetics to demonstrate the integral role of long non-coding RNAs in dosage compensation. Journal Club In this Journal Club, Daniel Masiga recalls a 1986 publication by C. H. Green, which revealed how colour and odour cues influence tsetse fly (Glossina spp.) attraction, and a 2019 study by Attardo et al.

In this Journal Club, Nozomu Yachie recalls a 1999 paper by Pellegrini, Marcotte and colleagues that demonstrated how functional information, such as protein--protein interactions, could be revealed through patterns of genetic diversity across species.

Microbial genomics has yielded transformative insights into the ecology and evolution of microorganisms. Nature Reviews Genetics presents a Focus issue that explores how genomic approaches reveal microbial dynamics across ecological and evolutionary contexts.

In this Journal Club, Tzachi Hagai highlights a 2005 paper by Sawyer et al. that tested the functional relationship of evolutionary changes in immune genes with infection outcomes. Journal Club Jean Fan recounts a 2015 paper by Martincorena et al. that revealed oncogenic mutations in normal tissues, also highlighting how the latest spatial technologies can now be used to study the spatial contextual impact of these mutations.

For the 25th anniversary of Nature Reviews Genetics, we reflect on exciting progress towards decoding the regulatory genome and its mechanisms, a central goal in genetics that must be solved with interdisciplinary research to yield widespread insights into evolution, development and disease. Editorial Top of page ⤴ In this Journal Club, Juan Fuxman Bass reflects on two papers, by Melnikov et al.

Gerald Mboowa reflects on the dual legacy of a 2021 study by Frangoul et al., which demonstrated safe and effective CRISPR-based editing to treat sickle-cell disease and β-thalassemia, as both a triumph of modern science and a call to action for global health.

In this Journal Club, Chikara Furusawa reflects on a 1991 publication by Tom Ray that presented Tierra, an evolvable computer program that pioneered the use of artificial life to study biological phenomena.

In this Journal Club, Josué Barrera-Redondo and Susana Coelho recount a 2012 paper by Carvunis et al. that provided a powerful framework for studying de novo gene evolution. Journal Club In this Journal Club, Jian Shu recalls a 2006 publication by Takahashi and Yamanaka as well as a 2021 paper introducing AlphaFold to discuss the fascinating potential of cellular reprogramming in the age of artificial intelligence.

In this Journal Club, Diyendo Massilani recalls two studies by Meyer et al. that reported a mitochondrial genome and nuclear DNA sequences from mid-Ice Age Sima de los Huesos hominins. Journal Club In this Journal Club, Delilah Hendriks and Benedetta Artegiani recall a 2018 paper by Lee et al. that combined data from human patients and experimental model systems to reveal the complexities of how brain tumours originate. Journal Club Hakhamanesh Mostafavi recalls a landmark paper by Boyle et al.

In this Journal Club, Kelley Harris recalls a 2003 paper by Goriely et al. that identified interesting evolutionary forces acting on mutations that are beneficial for cells within our bodies but detrimental to the health of our children. Journal Club In this Journal Club, Tracy Bedrosian describes a 2001 paper by Rehen et al. that provided early evidence of pervasive somatic variation throughout the human brain.