The Journal of Urology

BASED ON GUIDELINES, THE MANAGEMENT OF UNCOMPLICATED RECURRENT UTIs IS PRIMARILY BASED ON ANTIBIOTIC THERAPY. WHAT HAPPENS TO THOSE WHO FAIL? UTIs represent the most common bacterial infections worldwide and are associated with profound social, clinical, and economic effects.

Abbreviations and Acronyms 95% CI 95% confidence interval AUA American Urological Association DRE Digital rectal exam ERSPC European randomized study of screening for prostate cancer GG Grade group GRADE Grading of Recommendations Assessment, Development, and Evaluation mpMRI Multi-parametric magnetic resonance imaging MRI Magnetic resonance imaging NND Number needed to diagnose NNS Number needed to screen PBCG Prostate biopsy collaborative group PCPT Prostate cancer prevention trial PI-RADS...

INTRODUCTION AND OBJECTIVE: Long COVID, a chronic condition following SARS-CoV-2 infection, has raised concerns regarding its effects on the male reproductive system, particularly viral persistence in immune-privileged sites, such as the testis. This study investigates whether SARS-CoV-2 can be detected in the semen of patients recovering from mild and moderate COVID-19, examining viral persistence up to six months post-infection.

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INTRODUCTION AND OBJECTIVE: Prostate cancer is the second leading cause of cancer death in men in the United States, accounting for more than 34,000 deaths in 2023. Prior research suggests that prostate cancer mortality is highest in areas underserved by Urologists. We investigated contemporary associations between the density of urologists, radiation oncologists, and primary care physicians and prostate cancer mortality to inform strategic healthcare resource allocation.

INTRODUCTION AND OBJECTIVE: A changing healthcare landscape with increased practice costs, evolving administrative and regulatory requirements, and declining Medicare reimbursements has put significant financial pressure on physician-owned urology practices. Employed practice may offer urologists an alternative model for navigating the business of medicine. We aimed to examine shifts in urologists’ practice types over the past decade.

INTRODUCTION AND OBJECTIVE: Bladder sarcomas are a rare group of malignancies, with most of the data published comprised mostly of single center cohorts. This National Cancer Data Base (NCDB) is a national hospital-based registry, that includes more the 1,500 sites. In this study we used the NCDB to explore bladder sarcomas in the United States, utilizing the database advantages of its size, breadth, and inclusion of treatments given, as well as survival.

INTRODUCTION AND OBJECTIVE: Increasing evidence suggests that anti-cholinergic medications (ACM) for overactive bladder (OAB) are associated with an increased risk of dementia. Some studies suggest that certain ACM are safer than others due to their pharmacologic properties.

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Abstract Background: Nadofaragene firadenovec-vncg is a non-replicating adenoviral vector–based gene therapy for BCG-unresponsive carcinoma in situ (CIS) with/without HG Ta/T1). We report outcomes following 5 years of planned follow-up. Methods: This open-label phase 3 trial (NCT02773849) enrolled patients with BCG-unresponsive NMIBC in 2 cohorts: CIS ± Ta/T1 (CIS; n = 107) and Ta/T1 without CIS (Ta/T1 cohort; n = 50).