Chromatography Today

Waters Corporation has introduced 1 mm internal diameter liquid chromatography columns with MaxPeak Premier Technology to enhance analytical sensitivity, reduce solvent consumption and improve recovery for complex biomolecules in high-throughput pharmaceutical and biopharmaceutical laboratories Waters Corporation has launched 1 mm internal diameter liquid chromatography (LC) columns that incorporate the firm’s MaxPeak Premier Technology across its ACQUITY, BioResolve and GTxResolve brands.

Southwest Research Institute has developed a novel ion-assisted chromatography method that uses calcium salts to purify highly polar compounds at lower cost, with potential applications in peptide-based drug discovery Southwest Research Institute (SwRI) scientists have developed a novel purification method that improves chromatography results without the need for costly materials or specialist equipment.

Testa Analytical has introduced Trinity, a high-performance triple detector system for Gel Permeation Chromatography / Size Exclusion Chromatography (GPC/SEC), building on decades of expertise in macromolecular characterisation. Designed for complete and accurate analysis of proteins, polysaccharides, and synthetic polymers, Trinity integrates advanced chromatographic detector technologies with powerful yet intuitive software in a single platform.

A British-based research team has reported a detailed protocol for the use of anion-exchange chromatography mass spectrometry (AEC–MS) in metabolomics, expanding the scope of applications for this analytical technology. The method, which couples ion-exchange chromatography and mass spectrometry via electrolytic ion suppression, allows for the highly selective analysis of polar and ionic compounds and has proved valuable in environmental chemistry, food chemistry, forensics, and cell biology.

Biotech Fluidics has introduced a new peristaltic tubing stop adapter, further expanding its comprehensive range of barbed connectors designed to keep flexible tubing securely in place during operation. This latest adapter removes the need for fixed stoppers, making it possible to use custom-cut lengths of peristaltic tubing on any pump head size. The design allows tubing to be pushed onto a specially engineered nose and locked firmly with a retainer sleeve, ensuring a robust and reliable hold.

Tirzepatide acts as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonist, making it an effective treatment of type 2 diabetes with hypoglycemic and weight-loss effects. Due to their clinical value and pharmacological reliability, GLP-1 receptor agonists occupy a firm position in the global pharmaceutical landscape.

Researchers at Stellenbosch University have reported the first evidence of flavoalkaloids in cannabis leaves, identifying 79 phenolic compounds across three strains.

Open Access: Nature Scientific Reports This study investigated the migration of bisphenol A (BPA) from polyethylene terephthalate (PET) bottles into Iranian yogurt drink (Doogh), under different storage conditions and assessed the associated health risks. Three doogh brands were analyzed under different temperatures (4 °C, 25 °C, 45 °C), storage time (7–60 days), and light conditions (direct sunlight vs.

Plasmid DNA (pDNA) is a small, circular DNA molecule found in bacteria. Unlike chromosomal DNA, it replicates independently. These unique properties make pDNA an indispensable tool in biotechnology and pharmaceutical research. To meet the growing demand in these fields, large quantities of pDNA are required. However, not all isoforms are equally functional. Open circular and linear forms often result from mechanical or chemical stress and are significantly less effective.

Researchers in India have developed and validated a robust reverse-phase high-performance liquid chromatography (RP-HPLC) method to analyse orlistat, a leading anti-obesity drug. The method, published in Current Pharmaceutical Analysis, complies with International Council for Harmonisation (ICH) guidelines and has shown high accuracy, precision, and cost-effectiveness.