Immuno-Oncology Technology
VerifiedJournal
Immuno-Oncology Technology (IOTECH) is a new, peer-reviewed open access journal from ESMO publishing high quality original research articles, reviews, technology explained papers and editorials focusing on novel immuno-oncology topics and developments, both clinically and preclinically. Source
Actions
Media Outlet details
| Scope | International |
|---|---|
| Language | English |
| Country | United States of America |
Similarweb UVM
|
Request pricing |
Comscore UVM
|
Request pricing |
| Accepts contributed content | Yes |
Recent Articles
Search ArticlesTCR sequencing: applications in immuno-oncology research
Source of T cells driving clinical response to ICB Whether the key mechanism underpinning ICB response is through driving novel T cells into tumours (termed ‘T-cell clonal replacement’) or reinvigoration of pre-existing TILs (termed ‘T-cell clonal revival’) is under debate ( Figure 3 ). 52 Pauken K.E. Lagattuta K.A. Lu B.Y. et al. TCR-sequencing in cancer and autoimmunity: barcodes and beyond.
Table of Contents
Please select at least one article in order to proceed.
CD47-SIRPα-targeted therapeutics: status and prospects
Highlights • CD47 is a “don’t eat me” signal overexpressed on cancer cells. • Blockade of the CD47–SIRPα signaling pathway leads to phagocytosis of tumor cells. • CD47–SIRPα blockade plus standard treatment shows promising clinical efficacy. • Clinically, CD47–SIRPα blockade plus standard treatment is well tolerated. • Clinical trials targeting CD47–SIRPα in hematologic and solid tumors are ongoing.
The (re)discovery of tumor-intrinsic determinants of immune sensitivity by functional genetic screens
Highlights • CRISPR-Cas9 screens shed light on tumor-intrinsic mechanisms of immune sensitivity. • Different screen settings highlight tumor-intrinsic and environmental influences. • Effects of IFN-γ and antigen presentation pathways depend on environmental contexts. • Cellular context impacts how TNF and autophagy pathways affect immune sensitivity. • Potential therapeutic targets identified in the TNF, autophagy and IFN-γ pathways.