Fight Aging!
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All in all our relationship with aging leaves much to be desired. A majority of the public thinks of aging as inevitable and even desirable, a fact of life written in stone rather than a medical condition that may one day be curable. Comparatively few people know that the effects of aging can be modestly slowed by lifestyle choices such as calorie restriction, just as is the case for many other medical conditions. While this is beginning to change, ongoing research aimed at repairing known types of age-related cellular damage in order to produce true rejuvenation, the prevention and reversal of frailty and disability in the old, does not receive the widespread publicity and support it deserves. Source
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Recent Articles
Search ArticlesTargeted Reduction of PTBP1 Reverses Cognitive Impairment in a Mouse Model of Alzheimer’s Disease
Targeted Reduction of PTBP1 Reverses Cognitive Impairment in a Mouse Model of Alzheimer's Disease Permalink (With Comments) Permalink (No Comments) Posted by Reason Many of the more sophisticated forms of medicine, including gene therapies and immunotherapies, are challenging to deliver to the brain. At the very least there are far fewer practical options for delivery, and it is possible that none of that that exist fit a given desired use case.
Suggesting ERBB4 Overexpression as an Important Mechanism in Alzheimer’s Disease
Suggesting ERBB4 Overexpression as an Important Mechanism in Alzheimer's Disease Permalink (With Comments) Permalink (No Comments) Posted by Reason Researchers here suggest that increased ERBB4 expression in neurons is an important driving mechanism in the onset and progression of Alzheimer's disease.
Offspring of Centenarians Exhibit Reduced Mortality and Risk of Age-Related Disease
Offspring of Centenarians Exhibit Reduced Mortality and Risk of Age-Related Disease Permalink (With Comments) Permalink (No Comments) Posted by Reason This is far from the only study to indicate that the children of long-lived individuals tend also to be long-lived. The open question is the degree to which this is genetic versus cultural transmission.
Senescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain
Senescent Microglia Secrete DLK1, Which Causes Dysfunction in the Aging Brain Permalink (With Comments) Permalink (No Comments) Posted by Reason Senescent cells accumulate with age in tissues throughout the body, disrupting tissue structure and function with inflammatory secretions. The growing burden of senescent cells is an important contributing cause of degenerative aging.
Genome Sequencing of Bat Species in Search of Causes of Longevity
Genome Sequencing of Bat Species in Search of Causes of Longevity Permalink (With Comments) Permalink (No Comments) Posted by Reason Long-lived bats are extreme outliers in the normal mammalian relationships between species body size, metabolic rate, and life span. They are small, have a high metabolic rate, and unlike near all other mammals with those characteristics, many bat species are long-lived.
Clonal Hematopoiesis Associates with Idiopathic Pulmonary Fibrosis
Clonal Hematopoiesis Associates with Idiopathic Pulmonary Fibrosis Permalink (With Comments) Permalink (No Comments) Posted by Reason Clonal hemotopoiesis is the emergence of patterns of potentially problematic mutations occurring in hematopoietic stem cells that then spread over time throughout the immune system, as these stem cells are the source of all immune cells.
Senescent Cells in Metabolic Disorders
Senescent Cells in Metabolic Disorders Permalink (With Comments) Permalink (No Comments) Posted by Reason The most common metabolic diseases, such as type 2 diabetes or fatty liver disease leading to metabolic dysfunction-associated steatohepatitis (MASH), a fibrotic condition of the liver, are consequences of the dysfunctional state of metabolism that results from being overweight and sedentary.
An Adiponectin Receptor Agonist Promotes Muscle Growth in Rats
An Adiponectin Receptor Agonist Promotes Muscle Growth in Rats Permalink (With Comments) Permalink (No Comments) Posted by Reason The research community remains very interested in finding novel ways to promote muscle growth with minimal side effects. Therapies that inhibit myostatin or upregulate follistatin signaling are under development, and follistatin gene therapies have been available via medical tourism for some years.
Different Parts of the Brain Exhibit Different Vulnerability to Synucleinopathy
Different Parts of the Brain Exhibit Different Vulnerability to Synucleinopathy Permalink (With Comments) Permalink (No Comments) Posted by Reason Parkinson's disease and Lewy body dementia are synucleinopathies, characterized by the spread of misfolded α-synuclein through the central nervous system. The presence of misfolded α-synuclein provokes harmful changes in cell behavior and ultimately cell death in important populations of neurons.
Immune System Signatures Correlate with the Near Term Risk of Developing Atherosclerosis
Immune System Signatures Correlate with the Near Term Risk of Developing Atherosclerosis Permalink (With Comments) Permalink (No Comments) Posted by Reason Atherosclerosis is universal; everyone develops fatty atherosclerotic plaques in their arteries at some point, and to some degree. Plaques narrow blood vessels to impede blood flow, and rupture of unstable plaque causes heart attack, stroke, and embolism.