Fight Aging!

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All in all our relationship with aging leaves much to be desired. A majority of the public thinks of aging as inevitable and even desirable, a fact of life written in stone rather than a medical condition that may one day be curable. Comparatively few people know that the effects of aging can be modestly slowed by lifestyle choices such as calorie restriction, just as is the case for many other medical conditions. While this is beginning to change, ongoing research aimed at repairing known types of age-related cellular damage in order to produce true rejuvenation, the prevention and reversal of frailty and disability in the old, does not receive the widespread publicity and support it deserves. Source

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Impaired Glymphatic Drainage of Cerebrospinal Fluid in Early Stages of Synucleinopathy

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Impaired Glymphatic Drainage of Cerebrospinal Fluid in Early Stages of Synucleinopathy Permalink (With Comments) Permalink (No Comments) Posted by Reason Age-related impairment of drainage of cerebrospinal fluid from the brain is a topic of increasing interest.
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Assessing the Merits of Trained Immunity via BCG Vaccination to Treat or Prevent Alzheimer’s Disease

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Assessing the Merits of Trained Immunity via BCG Vaccination to Treat or Prevent Alzheimer's Disease Permalink (With Comments) Permalink (No Comments) Posted by Reason Vaccinations can produce a lasting effect known as trained immunity, altering the behavior of the innate immune system and resulting in both a reduction in the chronic inflammation of aging and a more effective immune response to unrelated infectious agents.
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Senescent Cells Contribute to Damage and Dysfunction Following a Heart Attack

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Senescent Cells Contribute to Damage and Dysfunction Following a Heart Attack Permalink (With Comments) Permalink (No Comments) Posted by Reason Senescent cells are involved in tissue regeneration. Cells enter a senescent state following injury, and in the usual course of events assist in the intricate coordination between immune cells, stem cells, and other cell types that is required to regrow tissue. These senescent cells are then cleared by the immune system.
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Senolytic Treatment with Dasatinib and Quercetin Rejuvenates the Aging Kidney in Mice

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Senolytic Treatment with Dasatinib and Quercetin Rejuvenates the Aging Kidney in Mice Permalink (With Comments) Permalink (No Comments) Posted by Reason There is a large body of evidence in animal studies to show that treatment with dasatinib and quercetin clears a fraction of the lingering senescent cells present in tissues throughout the body to restore more youthful function to many different organs and systems.
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Known Ways in Which the Gut Microbiome Influences Aging of Muscle and Brain

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Known Ways in Which the Gut Microbiome Influences Aging of Muscle and Brain Permalink (With Comments) Permalink (No Comments) Posted by Reason Animal studies suggest that the composition of the gut microbiome is at least as important as diet and exercise when it comes to influencing the pace and progression of aging. Both diet and exercise influence the gut microbiome as well - nothing in the body acts in isolation.
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Vascular Organoids to Regrow Microvessels in Heart Tissue

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Vascular Organoids to Regrow Microvessels in Heart Tissue Permalink (With Comments) Permalink (No Comments) Posted by Reason Researchers here describe an approach to encouraging regrowth of small vessels in heart tissue, involving transplantation of organoids composed of the various cell types needed to form new vessels. Like other cell therapy strategies for an injured or aged heart, delivery involves making a patch of pseudo-tissue that is layered onto the surface of the heart.
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SIRT6 Variants Found in Centenarians Produce a Lower Burden of Cellular Senescence

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SIRT6 Variants Found in Centenarians Produce a Lower Burden of Cellular Senescence Permalink (With Comments) Permalink (No Comments) Posted by Reason The point of studying the biochemistry of very long-lived humans is to try to better understand which of the many underlying mechanisms of damage and dysfunction that drive degenerative aging are the most important and thus should be prioritized for the development of therapies.
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Arc is Involved in Transmission of Tau Between Neurons in Alzheimer’s Disease

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Arc is Involved in Transmission of Tau Between Neurons in Alzheimer's Disease Permalink (With Comments) Permalink (No Comments) Posted by Reason The more severe later stages of Alzheimer's disease are characterized by altered forms of tau protein aggregating inside neurons to cause dysfunction, inflammation, and cell death. Researchers here show that tau can spread between neurons via extracellular vesicles, and identify the protein arc as necessary to this process.
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Imidazole Propionate Generated by Gut Microbes Accelerates Neurodegeneration

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Imidazole Propionate Generated by Gut Microbes Accelerates Neurodegeneration Permalink (With Comments) Permalink (No Comments) Posted by Reason The gut microbiome generates a vast range of metabolites, some beneficial or even necessary to health, and some actively harmful, provoking chronic inflammation or other dysfunction. With age the balance of microbial populations making up the gut microbiome changes for the worse.
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Retinal Endothelial Cells Derived from Induced Pluripotent Stem Cells Repair Damaged Retinas in Mice

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Retinal Endothelial Cells Derived from Induced Pluripotent Stem Cells Repair Damaged Retinas in Mice Permalink (With Comments) Permalink (No Comments) Posted by Reason The retina is considered a part of the central nervous system. As is the case for the brain, a barrier of specialized cells surrounding the blood vessels supplying retinal tissue controls the passage of molecules between blood and tissues.
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