Genetic Engineering & Biotechnology News

Home Topics Bioprocessing Bioprocessing’s Green Shift Gains Momentum Credit: CRB Group As bioprocessing companies race to meet ambitious sustainability goals, the industry’s biggest environmental challenges are becoming increasingly clear, and increasingly solvable.

Home Topics Bioprocessing Allogeneic CAR T Company Prepares to Widen Access to Patients CAR T cells attacking cancer cell. [Design Cells/Getty Images] A CAR T-cell therapy company using donor cells is planning to move to a pivotal Phase III clinical trial thanks to their genome editing strategies and optimization of their product, including choice of donors under 30.

Home Topics Bioprocessing Five Steps to Enable Self-Optimizing Process Purification Two women wearing safety workwear seen in a pharmaceutical laboratory in front of the complex machine that is the part of drug manufacturing. Self-optimization is the next evolutionary step for bioprocessing purification systems and, although that step is near, it currently is hindered by missing integrations among its many parts and by loose usage of precise concepts.

Home Topics Bioprocessing Software Can Solve CGT’s Sectors Traceability Challenges Credit: Sigrid Gombert/Getty Images The most important role of industrial software for the cell and gene therapy sector is the ability to precisely trace materials from collection site through the plant and back to the patient. So says Jonathan Wofford, CCO at Phoenix, Arizona software developer, Title21 Health Solutions, who told GEN, “CGT manufacturing typically involves fragmented, bespoke workflows.

The days of biotech businesses and institutions limiting their research and commercial activity to top clusters like Boston/Cambridge, MA, and the San Francisco Bay Area are passing, as the life sciences expand their horizons to regions and states not usually thought of as hotspots for the industry.

Home Topics Infectious Diseases Steroid Curbs Chronic Lung Inflammation Without Weakening Immune Defenses Credit: Andrzej Wojcicki/Science Photo Library/Getty Images Nontuberculous mycobacterial infections have become an increasing concern for people with chronic lung disease, in part because the infections can linger despite months of antibiotic treatment.

Home Topics Drug Discovery Parasite-Specific Protein Helps Toxoplasma Adapt to Crowded Conditions Toxoplasma parasites are shown in green, with host and parasite nuclei in blue. The iron-sulfur cluster assembly protein ISCU, shown in magenta, localizes to the parasite mitochondria and highlights their structure. ISCU is one of the targets regulated by TgPRO. [Whitehead Institute/Lourido Lab] Toxoplasma gondii is a parasite that infects hundreds of millions of people around the world.

John Maraganore, PhD Co-Founder and Executive Chair City Therapeutics Panelist John Maraganore, PhD John Maraganore, PhD, is a co-founder and executive chair of City Therapeutics. He was the founding CEO and a director of Alnylam Pharmaceuticals, the leading RNAi therapeutics company, which he led for nearly 20 years from 2002 to 2021. John built Alnylam from early platform research on RNAi through global approval and commercialization of the first five RNAi medicines.

Home News Human iPSC-Derived Heart Assembloids Reproduce Valve Development and Disease Credit: Mohammed Haneefa Nizamudeen / Getty Images/iStockphoto A multi-disciplinary, multi-institutional group of researchers said they relied on their expertise in genetics, mechanics, chemistry, and biology to create a chip the size of a postage stamp to model a particular class of heart conditions.

Sponsored content brought to you by Much has been written about how bispecific antibodies have expanded the biologics landscape by making it possible to engage multiple targets simultaneously and unlock new mechanisms of action. But their structural complexity introduces significant workflow challenges for downstream purification that are often more pronounced than those associated with traditional monoclonal antibodies. Figure 1: Bispecific antibodies come in a multitude of different formats.