HMP Global Learning Network

Three genes associated with immune cell infiltration may represent promising diagnostic biomarkers and future therapeutic targets in psoriasis, according to a study examining the molecular mechanisms underlying T cell–driven inflammation. Psoriasis is a chronic inflammatory skin disease characterized by dysregulated immune responses, with T cells playing a central role in disease pathogenesis.

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Researchers have developed and internally validated prediction models designed to identify patients with psoriasis at increased risk for psoriatic arthritis (PsA), with the goal of supporting earlier referral and disease detection. Because PsA is frequently underdiagnosed and delayed diagnosis is associated with poorer outcomes, investigators sought to identify predictors present at psoriasis onset and create models for both concurrent and future PsA risk.

Most adults with atopic dermatitis (AD) receiving long-term treatment did not achieve a comprehensive treat-to-target goal that incorporated both physician- and patient-reported outcomes, according to a real-world cross-sectional study. Investigators evaluated 100 adults with AD who had received treatment for at least 6 months.

Research exploring the relationship between atopic dermatitis (AD) and inflammatory bowel disease (IBD) has grown substantially over the past 2 decades, with increasing emphasis on shared disease mechanisms and translational therapeutic strategies, according to a bibliometric analysis. AD and IBD are epidemiologically linked and share several pathogenic features, including barrier dysfunction, immune dysregulation, and microbial dysbiosis.

An artificial intelligence (AI)-assisted systematic review has synthesized evidence across genetic, immune, microbial, and metabolic biomarkers in childhood atopic dermatitis (AD), providing a systems-level framework for understanding disease pathogenesis while identifying biomarkers supported by the strongest evidence. Childhood AD remains one of the most common inflammatory skin diseases and a major source of disease burden.

Artificial intelligence and intelligent diagnostic technologies are poised to play an increasingly important role in psoriasis management, according to a bibliometric analysis examining 2 decades of research on smart diagnosis and treatment. Psoriasis is a chronic inflammatory disease driven by genetic, immune, and environmental interactions.

Expert Insights Drs Raymond Cross and Dana Lukin review isolated ulcerative proctitis, including risk factors, diagnosis, mimics, and cancer surveillance. Raymond Cross, MD, is Medical Director, The Center for Inflammatory Bowel and Colorectal Diseases​, The Melissa L. Posner Institute for Digestive Health and Liver Disease at Mercy Medical Center​, in Baltimore, Maryland​.

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