The Journal of Clinical Endocrinology & Metabolism
VerifiedJournal
The Journal of Clinical Endocrinology & Metabolism is the world’s leading peer-reviewed journal for the dissemination of original research as it relates to the clinical practice of endocrinology, diabetes, and metabolism. Spanning the full spectrum of translational research from discovery science to experimental medicine and from critical evaluation of new treatments to patient-population-related outcomes, each issue provides up-to-date coverage of novel developments that enhance our understanding of the pathophysiology, diagnosis, and treatment of endocrine and metabolic disorders. JCEM also publishes articles that reveal insight into the metabolic-endocrine basis for, or treatment of, other human conditions including cardiovascular disease, cancer, and aging. Over and above new findings submitted from researchers across the globe, regular features of special interest include personal perspectives and commentaries on new developments, results of prismatic clinical trials, mini-reviews, and clinical practice guidelines. Source
Actions
Media Outlet details
| Scope | International |
|---|---|
| Language | English |
| Country | United States of America |
| Media Market | Washington-Hagerstown |
Similarweb UVM
|
Request pricing |
Comscore UVM
|
Request pricing |
| Frequency | Monthly |
| Accepts contributed content | Yes |
Recent Articles
Search ArticlesEffects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism
Liver fat is reduced within days after a low-carbohydrate diet substituted with fat to maintain isocaloric conditions. Investigate the effect of matched carbohydrate restriction during isocaloric and hypocaloric conditions on liver fat and postprandial glucose and lipid metabolism.
MCT8 deficiency in females
Monocarboxylate transporter (MCT) 8 facilitates thyroid hormone transport across the blood-brain-barrier. Pathogenic variants in SLC16A2 cause MCT8 deficiency (Allan-Herndon-Dudley syndrome), characterized by intellectual and motor disability and abnormal thyroid function tests. MCT8 deficiency typically affects males due to its X-linked inheritance.
Association Between Free Triiodothyronine and Diabetic Peripheral Neuropathy in Euthyroid Patients With Type 2 Diabetes
To explore the relationship between free triiodothyronine (FT3) and diabetic peripheral neuropathy (DPN) in Euthyroid patients with type 2 diabetes mellitus We enrolled 1422 hospitalized patients with type 2 diabetes from Zhongshan Hospital, Fudan University.
Ethanol Ablation of Metastatic Lymph Nodes in Patients with Papillary Thyroid Carcinoma - Predictors of Clinical Outcome
Ethanol Ablation (EA) is a treatment option in recurrent or persistent metastatic lymph nodes (MLN) from Papillary Thyroid Carcinoma. To assess whether ultrasonographic characteristics of the MLN, history of lymph node surgery, aggressive histological subtype, or BRAF V600E mutation in the primary tumor predict long-term response from EA. Seventy-five patients who received EA at a tertiary referral center were included.
Qualitative and Quantitative Analyses of Noninvasive Diagnosis of Insulinoma Using [18F]FB(ePEG12) 12-Exendin-4 PET/CT
This study represents the first interim report from a phase 2 clinical trial. Accurate localization of insulinomas remains a clinical challenge despite the availability of various imaging modalities. The current study aimed to evaluate the efficacy of positron emission tomography/computed tomography (PET/CT) using [18F]FB(ePEG12)12-exendin-4 (18F-exendin-4), a novel 18F-labeled PEGylated glucagon-like peptide 1 (GLP-1) receptor-targeted imaging probe, for the noninvasive detection of insulinomas.
Familial associations of the metabolic syndrome and its interrelated traits in Southwestern Indigenous Americans
Metabolic syndrome (MetS) risk factors emerge in childhood. The precursors may include familial association through genetic inheritance or cohabitation. Examine cross-sectional associations of MetS components between spouses and between parents and their 5–19-year-old offspring. Data were obtained from 1,255 mother-father-offspring triads enrolled in a longitudinal study in an Indigenous community in Arizona (1965-2007).
Approach to the Patient with Metastatic Pheochromocytoma and Paraganglioma
Pheochromocytomas and paragangliomas (PPGLs) are rare neural crest-derived tumors with malignant potential and a highly variable natural history, where some patients achieve a cure through surgical resection, while others experience an aggressive and protracted disease course characterized by recurrence and metastasis. While currently no definitive curative treatment exists for metastatic PPGL, ongoing trials and advances in biology of the disease present a beacon of hope.
Optimal Levothyroxine Dosing Strategy for Immune Checkpoint Inhibitor-Related Hypothyroidism: A Retrospective Study
Immune checkpoint inhibitor (ICI)-related hypothyroidism is mostly irreversible and prompt thyroid hormone replacement therapy is crucial, especially for patients undergoing neoadjuvant immunotherapy. This study aimed to propose a novel titration strategy for ICI-related hypothyroidism, evaluate levothyroxine (LT4) dose differences between hypothyroidism patterns, and develop a predictive equation for the optimal LT4 dose.
Corticosteroid Use and Long-Term Changes in Weight and Waist Circumference: The Lifelines Cohort Study
Over the last decades, the prevalence of overweight and obesity has dramatically increased, resulting in significant obesity-related morbidity and mortality (1). Obesity is a chronic and progressive disease (2), usually with a multifactorial etiology where lifestyle, medication use, endocrine, psychosocial, and genetic factors can play a role in the development and maintenance of this condition (3, 4).
Early origins of polycystic ovary syndrome: bridging the hypotheses
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout. This content is only available as a PDF. © The Author(s) 2025.