The Journal of the National Cancer Institute (JNCI)

Among non-Hispanic Black men, esophageal cancer mortality rate fell by 4.6% each year from 2000 to 2023. In contrast, among non-Hispanic White men, mortality rate increased by 1.2% each year from 2000 to 2005, stabilized between 2005 and 2015, and decreased by 1.0% each year from 2015 to 2023. For non-Hispanic Black women, mortality rate decreased by 5.1% each year from 2000 to 2009 and by 3.1% each year from 2009 to 2023.

Despite controversy surrounding Advance Care Planning (ACP) in recent years, high-quality ACP can significantly enhance the care of patients with advanced cancer and improve outcomes for their caregivers.1-4 Why do we make the qualification of “high-quality ACP”?

The Alliance Reference Set Study is the first to compare different commercial multicancer detection (MCD) tests on a single set of clinical samples from patients with cancer and volunteers without cancer.1 Previously, the only similar study compared several prototype approaches for analyzing cell-free DNA, to determine the most promising analytes for further test development.2 They show that MCD tests have clinical validity but that none of those studied are outstanding, and the heterogeneity...

Rates of new cases of ovarian cancer decreased steadily from 15.3 to 10.6 cases per 100 000 from 2000 to 2022 for Non-Hispanic White women, a decrease of 1.8% per year. The rate of new cases declined by 0.8% per year among Non-Hispanic Black women; however, this decrease is not statistically significant. Starting in 2019, the rate of new cases for Non-Hispanic Black women reversed and increased by 3.0% per year through 2022, but this change is also not statistically significant.

The American Cancer Society’s 2025 report on the Status of Cancer Disparities in the United States describes persistent disparities in cancer mortality by race, ethnicity and social determinants of health (SDOH).1 From 2019 to 2023, cancer mortality rates were highest among Non-Hispanic American Indian/Alaska Native and Non-Hispanic Black people, compared with all other racial and ethnic groups.

Lynch syndrome is probably the most common inherited cancer susceptibility syndrome. Over the past decades, it has become apparent that this syndrome comprises a group of conditions caused by germline pathogenic variants (GPVs) in distinct DNA mismatch repair (MMR) genes, each associated with partially overlapping but distinguishable clinical features.1 The term “Lynch syndrome” was introduced in 1984 by C.

This is an Editor’s Note regarding Imane Chaib, Niki Karachaliou, Sara Pilotto, Jordi Codony Servat, Xueting Cai, Xuefei Li, Ana Drozdowskyj, Carles Codony Servat, Jie Yang, Chunping Hu, Andres Felipe Cardona, Guillermo Lopez Vivanco, Alain Vergnenegre, Jose Miguel Sanchez, Mariano Provencio, Noemi Reguart, Caicun Zhou, Peng Cao, Patrick C. Ma, Trever G.

This is a correction to Partha Basu, “Changing paradigms in colorectal cancer screening,” J. Natl. Cancer Inst., 2025, https://doi.org/10.1093/jnci/djaf267 In October 2025, a reader contacted the journal to report errors in this editorial. After review of the concerns, the editor and the author agreed that the final two sentences of the penultimate paragraph should be corrected to clarify the results of the test being discussed.

This is a correction to: Luis Eduardo Bravo, M Constanza Camargo, M Blanca Piazuelo, Nubia Muñoz, In memoriam: Pelayo Correa, MD (1927–2025), JNCI: Journal of the National Cancer Institute, 2025; https://doi.org/10.1093/jnci/djaf362 The attribution for the photograph used in this paper to corrected to: “Photograph courtesy of Universidad del Valle, Cali, Colombia.” instead of: “Photograph courtesy of the Correa family and Vanderbilt University Medical Center.” This work is written by (a) US...

We thank DrSun et al.1 for reading and taking interest in our work. Their comments align with issues already discussed in our article. Building on their observations regarding gaps in the field, we take this opportunity to further reflect on key limitations and potential research directions for acupuncture in oncology. Despite its methodological value in blinding and controlling for nonspecific effects,2 sham acupuncture faces significant challenges.