Journal of Cell Science

Open figure viewer Keywords: Cell vertex, Epithelium, Tricellular junction, BMP, TGF-β, E-Cadherin, Myosin II, Drosophila Subjects: Development and cell differentiation, Review commons, Signal transduction, Tissue morphogenesis Normal organ development and function rely on the dynamic remodeling of intercellular contacts, enabling tissues to reshape during homeostasis and in response to infection, inflammation and injury (Mira-Osuna and Le Borgne, 2024).

Open figure viewer Keywords: Cytoplasmic streaming, Organelle movements, Myosin XI, Actin filaments Subjects: Cytoskeleton, Molecular motors, Plant cell biology Dynamic organelle movements are one of the hallmarks of active cellular processes, such as cell growth, migration and division (Bornens, 2008; Chocano-Coralla and Vidali, 2024; Nebenführ and Dixit, 2018; Tominaga and Ito, 2015).

Open figure viewer Keywords: Beadex, LIM domain-only protein, Haematopoiesis, Phagocytosis, Transcriptional regulation, Profilin, Drosophila, Immunity Subjects: Cell biology of the immune system, Genetics Transcription factors form highly regulated, tightly organised networks that regulate tissue development both spatially and temporally (Zerella et al., 2023).

Open figure viewer How would you explain the main findings of your paper in lay terms? Our bodies rely on specialised immune cells called macrophages that hunt down and ‘eat’ invading microbes, in a process called phagocytosis. To do this, the cell has to rapidly reshape its internal skeleton, built from a protein called actin, into arms that reach out and engulf the germ.

Open figure viewer How would you explain the main findings of your paper in lay terms? Cells constantly receive information from their surroundings through receptors on their surface. When these receptors detect signals, they activate signaling pathways that allow cells to adapt, respond to changes in their environment and survive.

Author contributions Conceptualization: W.Z., Z.L., Y.S.S.; Data curation: W.Z., S.T., X.-y.-T, J.L., Z.L., Y.S.S.; Formal analysis: W.Z., Z.L., Y.S.S.; Funding acquisition: P.H., Z.L., Y.S.S.; Investigation: W.Z., Z.L.; Methodology: W.Z., J.L., Z.L., Y.S.S.; Project administration: W.Z., Z.L., Y.S.S.; Resources: Y.S.S.; Software: W.Z.; Supervision: Y.S.S.; Validation: W.Z.; Visualization: W.Z.; Writing – original draft: W.Z., Z.L., Y.S.S.; Writing – review & editing: W.Z., S.T., X.-y.-T,...

Open figure viewer The axon initial segment (AIS) is the main region of a neuron where action potentials are initiated. This requires the clustering of transmembrane ion channels, whose localisation in turn relies on the clustering of scaffold proteins that facilitate attachment of the channels to the cytoskeleton. However, the mechanisms driving the clustering of these scaffold proteins remains unclear.

Open figure viewer Under nutrient starvation, cells undergo autophagy to recycle cellular components. The cytoskeleton is known to play a key role in this, but the involvement of intermediate filament networks remains overlooked. Here, Quentin Frenger, Etienne Morel and colleagues (Frenger et al., 2026) use super resolution microscopy to study vimentin intermediate filaments during the early stages of starvation-induced autophagy in cultured mammalian cells.

Open figure viewer Keywords: Austrofundulus limnaeus, Anoxia, ATR, Cell cycle, Replication stress Subjects: Biochemistry, Cell biology and disease, Cell cycle, Imaging Maintaining a stable genome is a vital requirement for cell and organismal survival and proliferation, with errors in processes involved in genome maintenance potentially leading to disease, dysfunction and death (Tomasetti et al., 2017; Zeman and Cimprich, 2014).

Open figure viewer How would you explain the main findings of your paper in lay terms? Parkinson's disease is usually thought of as a brain condition, but the most common genetic cause – a variant in a gene called LRRK2 – also affects immune cells. We studied how this variant (called G2019S) affects macrophages, the immune cells responsible for clearing up damage and debris in our tissues. Macrophages contain small compartments called lysosomes that break down waste materials inside the cell.