Mapping Ignorance

Enzymes and other biomolecules are often anchored onto solid materials so they can be reused, purified more easily, and made more stable, a strategy biotechnology has relied on since industrial-scale immobilized enzymes first appeared in chemical manufacturing in the mid-twentieth century. Immobilized enzymes today drive processes from food and pharmaceutical production to biosensors and medical diagnostics. Fixing a biomolecule in place, however, is not as simple as gluing it down.

Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Chimeric antigen-specific receptor (CAR) T-cell immunotherapy targeting B-cell maturation antigen (BCMA; BCMA-CAR T cells) has produced remarkable clinical responses in advanced multiple myeloma (MM), with a substantial fraction of patients achieving complete remission 1. However, many patients relapse within months, largely due to insufficient CAR T-cell persistence, a recognized mechanism of acquired resistance 2.

Artificial intelligence is increasingly being used to solve the mathematical equations that describe the physical world, not only to recognize images or generate text. One promising approach, developed over the last decade, is the physics-informed neural network, or PINN: a type of neural network trained not on labeled examples but on the governing equations of a physical system.

Author: Jaume Navarro is an Ikerbasque Research Professor at the University of the Basque Country A few weeks after the invasion of Ukraine by the Russian army, many scientific institutions felt the need to issue public statements against that war. At the time, I was president of the Commission for the History of Physics within the International Union of Pure and Applied Physics (IUPAP) and, as such, I took part in the discussions leading to the final declaration.

One of the great unanswered questions in physics concerns the nature of neutrinos, the lightest known particles with mass. A process called neutrinoless double beta decay could provide the answer. In ordinary double beta decay, two neutrons inside a nucleus transform into two protons, emitting two electrons and two antineutrinos. In the neutrinoless version, only the electrons emerge.

For millennia, farming in Switzerland did not reduce plant diversity but helped increase it, researchers have shown in a detailed reconstruction covering the past 7000 years. Only recent decades paint a different picture. Aerial view of Hüttwilersee, one of three lakes in Switzerland that provided insights into 7000 years of plant diversity.

Authors: Sergi Muria Maldonado, Professor de Didàctica de les Matemàtiques, Universitat de Barcelona; Anton Aubanell Pou, Professor de l’Institut de Formació Continuada i professor jubilat de Didàctica de les Matemàtiques, Universitat de Barcelona, and Jordi Font González, Professor de Didàctica de les Matemàtiques, Universitat de Barcelona The basilica’s columns branch out, imitating the natrual structure of a tree.

Author: Tamara Cruz Tena, strategy consultant, CIC energiGUNE When energy storage is discussed in the context of the energy transition, the conversation almost invariably turns to electricity. Solar and wind power have made the temporal mismatch between energy production and energy demand one of the defining challenges of low-carbon energy systems, and technologies capable of storing electrical energy have consequently become central to discussions about decarbonization.

When astronomers in the eighteenth century first turned powerful telescopes toward the Milky Way, they noticed something puzzling: tight, spherical swarms of stars scattered across the sky. Now we know that each contains hundreds of thousands of suns packed into a region just a few dozen light-years across. These objects, known today as globular clusters, were beautiful curiosities for more than a century.

Author: Chris Kirkland, Professor of Geochronology, Curtin University In the Pilbara of Western Australia, some of Earth’s oldest rocks lie beneath the sky, as they have for billions of years. They are dark, weathered volcanic rocks, close to 3.5 billion years old, cut by veins and stewed by deep time. Their survival is remarkable. Most rocks this old have moved back into Earth’s interior. These ones, still on the surface, have changed, but not enough to erase their first story.