National Institutes of Health
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The National Institutes of Health (NIH) — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov. Source
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| Language | English |
| Country | United States of America |
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Recent Articles
Search ArticlesMetformin and clinical outcomes in hidradenitis suppurativa: A multi-institutional cohort study
Cite Display options Display options Format AbstractPubMedPMID No abstract available Keywords: biologics; healthcare utilization; hidradenitis suppurativa; metformin; retrospective studies. PubMed Disclaimer References Miller IM, Ellervik C, Vinding GR, Zarchi K, Ibler KS, Knudsen KM, et al. Association of metabolic syndrome and hidradenitis suppurativa. JAMA Dermatol. 2014;150(12):1273–1280. Jennings L, Hambly R, Hughes R, Moriarty B, Kirby B. Metformin use in hidradenitis suppurativa.
Norepinephrine infusion for prophylaxis against spinal-induced hypotension in elderly patients undergoing hip surgery: a randomized controlled comparison of two doses
Background: We aimed to compare the hemodynamic response to two norepinephrine infusion rates for prophylaxis against post-spinal hypotension in elderly population undergoing hip surgery. Methods: This randomized non-inferiority clinical trial included elderly patients scheduled for hip surgery under spinal anesthesia. Patients received norepinephrine infusion at a rate of 0.1 mcg/kg/min (0.1-mcg group) or 0.07 mcg/kg/min (0.07-mcg group) after spinal anesthesia.
The platelet-to-high-density lipoprotein cholesterol ratio as a potential biomarker linking tobacco exposure to accelerated reproductive aging in women: A cross-sectional study
Female reproductive aging, commonly reflected by menopausal age and reproductive lifespan, is influenced by environmental exposures and metabolic health, and tobacco exposure has been associated with earlier menopause and shortened reproductive lifespan.
[Retifanlimab as first-line treatment for locally recurrent or metastatic squamous cell carcinoma of the anal canal]
Cite Display options Display options Format AbstractPubMedPMID No abstract available Keywords: Anal canal; Canal anal; Carcinome épidermoïde; Immunotherapy; Immunothérapie; Retifanlimab; Rétifanlimab; Squamous cell carcinoma. PubMed Disclaimer Conflict of interest statement Déclaration de liens d’intérêts les auteurs déclarent ne pas avoir de liens d’intérêts.
Targeting TLR4-lipid rafts reverses hyper-excitability in pain-associated human dorsal root ganglia
Cite Display options Display options Format AbstractPubMedPMID Abstract Cholesterol-rich lipid rafts are organizing platforms for many excitatory ion channels and receptors in neurons and for inflammatory receptors like toll-like receptor 4 (TLR4) in immune cells. Human dorsal root ganglion (hDRG) neurons that express nociceptor markers also express high levels of TLR4.
Rapid Fc-mediated surface modification of liposomes with antibodies for selective targeting of pancreatic tumors
Cite Display options Display options Format AbstractPubMedPMID Abstract This study introduces a versatile platform for targeted drug delivery that addresses the complexities of conventional immunoliposome preparation.
The weakest link in digital atrial fibrillation screening: a randomized comparison of self-applied ECG patch systems in older adults
Cite Display options Display options Format AbstractPubMedPMID No abstract available Keywords: Atrial fibrillation; Digital health; ECG; Screening; Wearables. PubMed Disclaimer Conflict of interest statement Conflict of interest: none declared.
Noninvasive, Rapid, and Ultrasensitive Detection of Salivary Glycated Hemoglobin for Point-of-Care Testing of Diabetes
The glycated hemoglobin ratio (HbA1c %) serves as the gold standard for diabetes diagnosis, but traditional detection methods require invasive blood testing. Although saliva holds promising noninvasive potential, the complex salivary matrix and the low abundance of salivary hemoglobin (Hb) and glycated hemoglobin (HbA1c) restrict the development of reliable immunoassays.
Mediterranean Diet and Metabolic Outcomes in NAFLD/MASLD: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Non-alcoholic fatty liver disease (NAFLD), recently redefined as metabolic dysfunction associated steatotic liver disease (MASLD), is the most prevalent chronic liver disorder worldwide and is strongly associated with obesity, insulin resistance, and cardiometabolic risk. The Mediterranean diet (MD) has been proposed as a therapeutic strategy for improving metabolic and hepatic outcomes.
Resveratrol alleviates fenvalerate-induced cardiotoxicity in zebrafish larvae by inhibiting oxidative stress and apoptosis
Cite Display options Display options Format AbstractPubMedPMID Abstract Fenvalerate (FEN), a widely used an agricultural type II pyrethroid pesticide, has been found in the environment and human tissues. Nevertheless, the cardiotoxicity of FEN remains poorly understood. This study aimed to explore the cardiotoxicity of FEN and the potential cardioprotective role of resveratrol (RES, a polyphenolic antioxidant) in zebrafish.