Omic.ly

This is especially true when things go awry! Cells have mechanisms in place to degrade misbehaving proteins, eliminate things that aren’t needed anymore, or respond to crises by going nuclear. For cells, the nuclear options are autophagocytosis (self-eating), senescence (cell cycle arrest), apoptosis (programmed cell death), and necrosis (rapid, less programmed, cell death).

Their structure was published in the April 1953 issue of Nature along with two other papers on the same topic from Wilkins and Rosalind Franklin. Although they don't cite Franklin in their 1953 paper, they definitely used her data. It was Franklin's paper that included Raymond Gosling's pristine diffraction of B-DNA, known as Photo 51, that showed the structure of DNA is helical, it's double stranded, and the bases faced inward with the phosphate backbone on the outside.

Cool, here's what you need to know! The human microbiome is the entire community of microorganisms that live on or in your body and is made up of bacteria, fungi and viruses. Your body contains, or has on it, many different microbiomes. This is because each crack, crevice, surface, and orifice creates a distinct environmental niche that promotes the growth of totally different microorganisms! Meaning, your skin, your mouth, your armpits, and your gut have different microbiomes.

Single-cell transcriptomic profiling has emerged in recent years as a powerful tool for understanding the biology of complex cellular mixtures and tissues. It's been used extensively to look at how cells respond to changing environments, tease apart the dynamics of disease states, and track cell fates during development. And looking at single-cells is important because the activities of cell populations or rare individual cells can get washed out in bulk measurements of cellular material.

’We couldn’t live without it’: the UCSC Genome Browser turns 25 After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact. The Percentage of Tasks AI Agents Are Currently Failing At May Spell Trouble for the Industry The best AI Agents are currently failing about 70 percent of the tasks assigned to them, as investments are expected to drop off a cliff.

Genome editing technologies have improved significantly since the early days of plasmid preps and restriction digests. That's especially true now with the emergence of programmable nucleases like CRISPR. These tools enable precise modification of short DNA sequences (<200 bp) and have shown some clinical utility in treating genetic disorders. But efficiently inserting large DNA sequences (≥1 kb), or even complete genes, at specific genomic sites in human cells is still a challenge.

Linus Pauling is remembered as one of the greatest American scientists of all time. He was awarded two undivided Nobel Prizes, and is basically the father of modern structural biology. He's most famous for solving the 3D structure of the α-helix and the β-sheet, the two most common protein structures. To do this, Pauling employed a technique called x-ray crystallography which basically bombards a crystal with x-rays.

My brain was never more broken than when I tried to learn about SOLiD's color space but "Fuzzy Sequencing" is a close contender! If you remember the ABI SOLiD sequencer, it operated VERY differently than the sequencing by synthesis technology that has come to dominate sequencing for the past 2 decades. SOLiD was a "sequencing by ligation" technology that ligated fluorescently labeled nucleotide pairs together to determine the sequence of a target DNA molecule.

The word microbiome was first used to describe all of the microbes that inhabited a specific environment. Many of the words we use when talking about the microbiome come from ecology which is the study of how organisms (usually plants and animals) interact with each other and their environments. So, the microbiome is actually something that’s studied as a part of the field of microbial ecology which covers basically all of the different microbiomes.

Because once the structure was proposed, everyone needed something new to fight about. And one of those new topics was how a double stranded DNA helix was copied or 'replicated' to then be passed on to the next generation. There were three theories for how this might work: Conservative - A completely new copy of DNA is made that contains no pieces from the parental molecules.