Malaria is most common health problem in tropical areas that can lead to fatal complications including acute kidney injury. Plasmodium falciparum infection is one of leading cause of complicated malaria leading to death. Although the pathogenesis of acute kidney injury is not fully understood, however, blockage of renal microcirculation due to sequestration of red blood cells, immune mediated glomerular injury, and hypovolemia, play a pivotal role in causing acute of kidney dysfunction.