PNAS
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About PNAS
PNAS is one of the world's most-cited and comprehensive multidisciplinary scientific journals, publishing more than 3,300 research papers annually.
The Proceedings of the National Academy of Sciences (PNAS), the official journal of the National Academy of Sciences (NAS), is an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences. The journal is global in scope and submission is open to all researchers worldwide.
PNAS was established in 1914 in honor of the semicentennial anniversary of the National Academy of Sciences. Since then, we have worked to publish only the highest quality scientific research and to make that research accessible to a broad audience. In addition, PNAS publishes science news, Commentaries, Perspectives, Colloquium Papers, podcasts, and profiles of NAS members.
In 1995, PNAS began accepting Direct Submissions from researchers without an NAS affiliation. While we retain strong ties with the NAS, whose members oversee the journal’s rigorous three-tier peer review process, we now receive more than 17,000 Direct Submissions each year. Direct Submissions account for more than 75% of the research we publish.
PNAS is available by subscription, and all content is free after 6 months. Authors who choose the open access option can have their articles made available without cost to the reader immediately upon publication. Developing countries have free access to PNAS. Source
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| Scope | National |
|---|---|
| Language | English |
| Country | United States of America |
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| Accepts contributed content | Yes |
Recent Articles
Search ArticlesWhen does exercise hinder rather than halt tumor progression? The decisive role of immunotherapy responsiveness
A recent study published in PNAS provided the first systematic evidence that, in a 4T1 triple-negative breast cancer mouse model, mild caloric restriction combined with chemotherapy reduced primary tumor growth and pulmonary metastasis; however, the addition of voluntary exercise did not further suppress primary tumor growth and instead attenuated the protective effect of caloric restriction against lung metastasis (1).
Reply to Cosgrove: Catalytic activity in expansin-like proteins does not explain wall creep but raises a flag
In a thoughtful letter (1), Cosgrove comments on our discovery that a single-domain fungal expansin-like protein (ELP) called GtEXPN_133317 has catalytic activity on xylan (2). He points out that our findings do not prove that catalysis plays a role in wall creep caused by canonical two-domain expansins and rightfully adds that wall creep has never been demonstrated for single-domain ELPs, i.e., proteins that contain the DPBB domain but lack the CBM63 domain.
Reply to Zhou et al.: Exercise, caloric restriction, and immunotherapy responsiveness in 4T1 breast cancer progression
Reply to Zhou et al.: Exercise, caloric restriction, and immunotherapy responsiveness in 4T1 breast cancer progression In a Letter to the Editor in response to our recent PNAS publication, Zhou et al. propose a possible explanation for our findings regarding the effects of exercise on tumor progression (1, 2). They emphasize the importance of the tumor microenvironment (TME) and hypothesize that response to immunotherapy may be closely linked to the host’s capacity to benefit from exercise.
Response duration tracks confidence
Abstract The timing of behavioral responses is among the most robust signatures of cognitive processing—with easier, more accurate, and more confident judgments typically made more quickly. But which aspects of response timing carry these signals?
Polarons are probes of the dynamic nanoscale environments found in electrochemically doped π-conjugated polymers
E. L. Ratcliff et al., Soft materials for photoelectrochemical fuel production. ACS Energy Lett. 8, 5116–5127 (2023). S. Biswas, A. Chowdhury, Organic supercapacitors as the next generation energy storage device: Emergence, opportunity, and challenges. ChemPhysChem 24, e202200567 (2023). Z. Zhang et al., Conjugated polymers for flexible energy harvesting and storage. Adv. Mater. 30, 1704261 (2018). S. T. M. Tan et al., Redox-active polymers designed for the circular economy of energy storage devices.
The accuracy of electrostatic interactions captured by AI protein structure prediction models
L. A. Abriata, The Nobel prize in chemistry: Past, present, and future of AI in biology. Commun. Biol. 7, 1409 (2024). M. Baek et al., Accurate prediction of protein structures and interactions using a three-track neural network. Science 373, 871–876 (2021). Z. Lin et al., Evolutionary-scale prediction of atomic-level protein structure with a language model. Science 379, 1123–1130 (2023). J. Fleming et al., AlphaFold protein structure database and 3D-Beacons: New data and capabilities. J. Mol. Biol.
Catalysis does not explain expansin-mediated wall creep: Distinguishing catalytic ERPs from creep-active expansins
Delgado Santamaría et al. (1) report low but detectable xylan cleavage after 48-h treatments with high concentrations of GtEXPN_133317, a fungal single-domain ERP (“expansin-related protein”). They suggest that this finding may illuminate the mechanism by which expansins rapidly (<1 min) promote sustained wall creep, a process central to plant growth and potentially related to biomass accessibility.
Relative Thom conjectures, symplectic and beyond
P. B. Kronheimer, T. S. Mrowka, The genus of embedded surfaces in the projective plane. Math. Res. Lett. 1, 797–808 (1994). J. W. Morgan, Z. Szabó, C. H. Taubes, A product formula for the Seiberg-Witten invariants and the generalized Thom conjecture. J. Differ. Geom. 44, 706–788 (1996). P. Ghiggini, Ozsváth-Szabó invariants and fillability of contact structures. Math. Z. 253, 159–175 (2006). P. S. Ozsváth, Z. Szabó, Holomorphic triangles and invariants for smooth four-manifolds. Adv. Math. 202, 326–400 (2006). S. Gadgil, D.
Rapidly evolving composition of nebular infall recorded by magnesium isotopes in refractory inclusions
T. Lee, D. A. Papanastassiou, Mg isotopic anomalies in the Allende meteorite and correlation with O and Sr effects. Geophys. Res. Lett. 1, 225–228 (1974). Y. Amelin et al., U-Pb chronology of the solar system’s oldest solids with variable 238U/235U. Earth Planet. Sci. Lett. 300, 343–350 (2010). J. N. Connelly et al., The absolute chronology and thermal processing of solids in the solar protoplanetary disk. Science 338, 651–655 (2012). T. Lee, D. Papanastassiou, G.
IL-7–glucose–Aiolos axis orchestrates pathogenic CD8 + T cell function in spondyloarthritis
N. M. Chapman, M. R. Boothby, H. Chi, Metabolic coordination of T cell quiescence and activation. Nat. Rev. Immunol. 20, 55–70 (2020). M. Reina-Campos, N. E. Scharping, A. W. Goldrath, CD8+ T cell metabolism in infection and cancer. Nat. Rev. Immunol. 21, 718–738 (2021). S. Pokhrel et al., Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells in mice. Nat. Commun. 17, 839 (2025). K. A. Read, D. M. Jones, A. G. Freud, K. J.