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Engineered exosomes are emerging as a potential next-generation regenerative therapy for skin aging, according to a new review published in the FASEB Journal. The authors describe how bioengineered extracellular vesicles may overcome several limitations associated with conventional antiaging therapies while highlighting the scientific and translational hurdles that remain before routine clinical use.

Key Takeaways EZFB was associated with longer survival than regorafenib in the randomized third-line comparison. Response and disease control findings also favored EZFB over regorafenib. Adverse events and discontinuation of at least one study drug were more frequent with EZFB, while no treatment-emergent deaths or unexpected safety signals were reported.

Key Takeaways PETRUSHKA was associated with lower all-cause antidepressant discontinuation at 8 weeks than usual care. Fewer discontinuations due to adverse events were reported, and depressive and anxiety scores were lower at 24 weeks. The authors said that the lack of a double-blind design and substantial missing data limited the validity of the findings.

Key Takeaways Postpartum haemorrhage was less frequent with tranexamic acid than with placebo in women with placenta praevia undergoing caesarean delivery. Findings were similar across age, placenta praevia type, antepartum haemorrhage, and placenta accreta spectrum analyses, and sensitivity checks pointed in the same direction. Operating-room adverse events and serious adverse events through six weeks were reported at similar rates in both groups.

Key Takeaways GLP-1-based therapy was associated with lower risks of all-cause mortality, heart failure, adapted MACE, and all-cause hospitalization in matched adults with type 1 diabetes. No significant differences were observed for myocardial infarction, ischemic stroke, or chronic kidney disease. Hypoglycemia was lower, DKA was not increased, pancreatitis events were rare in both groups, and the authors said randomized trials are needed.

Private equity investment in dermatology continues at a rapid pace in 2026, with buyer demand remaining strong despite more than a decade of consolidation across the specialty, according to a new market update from Physician Growth Partners. Although consolidation began accelerating around 2014, the report notes that most dermatology practices remain independently owned.

Key Takeaways Liposomal bupivacaine was associated with lower pain scores within 72 hours and lower opioid consumption than ropivacaine hydrochloride. Greater joint range of motion and earlier time to first ambulation were reported with liposomal bupivacaine. Adverse events were similar, with early complications in one liposomal bupivacaine patient and two ropivacaine patients, none related to analgesic selection.

07/10/2026 Key Takeaways Rituximab was reported to meet the trial's prespecified noninferiority threshold versus ocrelizumab for the MRI lesion outcome from months 6 to 24. Relapse, disability, and cognitive-performance findings were reported as similar between groups, although those measures were summarized qualitatively. Infections were reported more often with rituximab, while serious adverse event rates were similar between groups.

07/10/2026 Key Takeaways The review included 160 studies, 16,639 parents, and 85 meta-analysis estimates assessing anxiety, depression, stress, and trauma symptoms with validated self-report questionnaires. Anxiety improved with bonding interventions, family-centered care and education, and psychotherapy and emotional support, while stress and depression improved with different category-specific patterns.

07/10/2026 Key Takeaways Home fecal calprotectin monitoring every 2 months was not associated with fewer symptomatic flares than standard care. No between-group differences were reported by disease extent or advanced therapy use, and secondary end points were also similar. The authors concluded that home monitoring without a protocolized escalation pathway did not prevent symptomatic flares, and that further study is needed.