Research Protocols

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JMIR Publications is the leading ehealth publisher, advancing progress in the health, engineering and social sciences to ultimately help people to live happier and healthier lives using technology. JMIR Publications helps innovators in the health technology space to collaborate and to disseminate their innovations, ideas, and research results to the widest possible audience. JMIR Publications is a rapidly growing innovative academic publisher. It builds on the success of JMIR (Journal of Medical Internet Research), which started in 1998 as a small independent open access project hosted at a university, which subsequently grew into the most influential journal in medical informatics (ranked #1 by Impact Factor by Thomson Reuters for three years, JIF>5.0) and health services research. Pioneer in #openaccess and #openscience, JMIR Publications is now also publishing a superjournal JMIRx as overlay journal on top of preprint servers. Source

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A Metacognitive Intervention for Children and Adolescents in Neuropediatric Care (Mio-Training): Protocol for a Randomized Controlled Trial

| Research Protocols
Design and Setting of the Study Figure 1. Study flow chart. T0: screening; T1: first assessment (before intervention or waiting period); T2: second assessment (immediately after intervention or waiting period); T3: third assessment (12 weeks after intervention or waiting period). Participants Overview Cancer Survivors Children and Adolescents With ADHD Healthy Controls Ethical Considerations Intervention Figure 2. Prototype of the Mio-Training app.
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Four-Week vs Six-Week Antibiotic Therapy in the Management of Nonsurgically Treated Diabetic Foot Osteomyelitis: Protocol for a Multicentric, Single-Blind Randomized Clinical Trial

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By Dibyendu Biswas
| Research Protocols
Trial Design Ethical Considerations Characteristics of the Groups and Interventions Randomization and Group Allocation Methodology Table 1. List of the allowed antibiotic treatments (empirical or targeted).
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Evaluating Client-Centered Counseling Approaches to Improve Contraceptive Uptake at Family Planning Centers in Rawalpindi, Pakistan: Protocol for a Pilot Cluster-Randomized Trial

| Research Protocols
Study Framework Figure 1. Conceptual framework of the study. Study Aim Study Design Study Setting Study Timeline Figure 2. SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) timeline of the study. GATHER: greet, ask, tell, help, explain, return.
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Correction: Challenges in Developing a Patient-Reported Symptom-Based Risk Stratification System for Suspected Head and Neck Cancer: Protocol for a Qualitative Case Study

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By Rebecca K. Randell
| Research Protocols
JMIR Res Protoc 2026;15:e100038 doi:10.2196/100038 In “Challenges in Developing a Patient-Reported Symptom-Based Risk Stratification System for Suspected Head and Neck Cancer: Protocol for a Qualitative Case Study” [], the authors noted one error. has been replaced with the file attached to this notice. The correction will appear in the online version of the paper on the JMIR Publications website, together with the publication of this correction notice.
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Evaluation of the Efficacy of Human Papillomavirus Screening Compared With Cytology Screening in Pregnant Women: Protocol for a Prospective Multicenter Trial

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By Taichi Mizushima
| Research Protocols
Figure 1. Current cervical cancer screening protocol in Japan. In the human papillomavirus (HPV) testing protocol, HPV-negative cases are scheduled for another HPV test in 5 years. HPV-positive cases undergo cervical cytology. For cases positive for HPV and atypical squamous cells of undetermined significance (ASC-US), colposcopy with or without cervical biopsy is performed immediately.
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KlimaNot—Effects of Climate Change on Emergency and Acute Care: Protocol for a Multicenter, Registry-Based Observational Cohort Study

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By Felix Walcher
| Research Protocols
Background Objectives Primary Objective (Prespecified Retrospective Analysis) Secondary Clinical Objectives (Retrospective; Secondary Endpoints) Ancillary Prospective Geriatric Substudy Exploratory Objectives (Hypothesis-Generating and Methodological Components) Study Design and Setting Table 1. Characteristics of participating AKTINa – EDsb (N=56).
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A Resiliency Intervention to Support Nurses Engaged in the Provision of HIV Care in KwaZulu-Natal, South Africa: Protocol for a Pilot Randomized Controlled Trial

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By Elyse R. Park
| Research Protocols
Background Theoretical Framework Figure 1. Overview of adapted Stress Management and Resiliency Training-Relaxation Response Resiliency Program model []. RR: relaxation response. aNovel components added to the model.
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Investigating the Association Between Volatile Organic Compounds and Preterm Birth in Detroit, Michigan: Protocol for the Center for Leadership in Environmental Awareness and Research Birth Cohort Study

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By Jennifer K. Straughen
| Research Protocols
Table 1. Volatile organic compound (VOC) metabolites to be measured in urine samples from participants in the Center for Leadership in Environmental Awareness and Research birth cohort study and major sources of exposure.
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Cross-Cultural Perspectives on Metabolic Syndrome Management and Attitudes Toward Using Digital Health Tools in Two Distinct Populations: Protocol for a Qualitative Descriptive Study

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By Ashish Joshi Verified
| Research Protocols
Background Conceptual Models Aims and Research Questions Question 1: What are the key barriers and facilitators to MetS self-management among individuals in the United States and the Middle East? This question seeks to identify individual, interpersonal, organizational, and community factors influencing self-care practices. Question 2: What individual, interpersonal, and community influences shape the adoption and use of digital tools for MetS management?
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An Explainable AI Framework for Continuous Monitoring, Risk Stratification, and Clinical Decision Support in Primary Biliary Cholangitis: Protocol for a Multiphase Development and Validation Study

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By Ulrick Sidney Kanmounye
| Research Protocols
Background Proposed Solution Study Aim Figure 1. Conceptual framework for the explainable artificial intelligence (AI) system for symptom and disease monitoring, early portal hypertension prediction, and remote clinical decision support (CDS) in primary biliary cholangitis (PBC).
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