Separation Science

Articles Master pre-run system suitability testing in HPLC under USP <621> and FDA guidelines. Learn to evaluate retention factor, peak tailing, theoretical plates, resolution, and sequence bracket repeatability.

Improve performance of SVOC extraction techniques used for aqueous samples, including separatory funnel liquid-liquid extraction, continuous liquid-liquid extraction, and solid phase extraction. Gain strategies for improving recovery of challenging compounds, such as phenols, NDMA, benzidine, 3,3'-dichlorobenzidine, and pyridine, within EPA Methods 8270 and 625 workflows.

Non-targeted analysis (NTA) is designed to find what researchers do not yet know to look for. That objective creates a fundamental sample-preparation challenge: laboratories must recover chemicals spanning a wide range of physicochemical properties while limiting matrix interference, instrument fouling, and background contamination.

Analytical reports routinely compress several questions into a single word: quality. A chromatographic percentage may be repeated as though it also names the principal peak and accounts for every impurity. In the opposite direction, agreement with an expected mass may be treated as a purity result. Both moves enlarge the measurement after the fact. Purity and identity are related, but they are not interchangeable.

By attending this webinar you will be able to: Evaluate which carrier gas is most appropriate for a given GC or GC-MS application, considering instrument configuration, analytical requirements, and method performance. Understand the practical considerations when transitioning from helium to hydrogen or nitrogen, including implications for chromatography, method translation, and routine analysis.

Articles Streamline method development, transition safely from helium to hydrogen carrier gas, and overcome matrix interferences in complex samples using expert frameworks from Diane Turner.

Articles Trace elusive contamination sources, eliminate syringe carryover, resolve split vent back-diffusion, and troubleshoot flatline baseline dropouts using expert diagnostic workflows from Diane Turner. Written byShiama Thiageswaran Presented byDiane Turner iStock Register for free to listen to this article Few issues in gas chromatography are as frustrating as running a blank solvent injection and seeing a cluster of unwanted peaks.

Video Experts at ASMS 2026 discuss fit-for-purpose throughput, laboratory economics, long-read proteomics, and the role of AI in more efficient mass spectrometry workflows. Written byAimee Cichocki InterviewingNeil Kelleher, PhD, Dr. Matthew Lewis, Warren Potts, James Hallam, Jose Castro-Perez, and Konstantinos Thalassinos How fast is fast enough in mass spectrometry? For laboratories handling large sample cohorts, the answer may seem simple: the more samples processed, the better.

Video Industry experts discuss how customer-led development, AI, automation, accessible software, and budget pressures are reshaping mass spectrometry. Written byAimee Cichocki InterviewingNeil Kelleher, PhD, Geoff Winkett, Rohan Thakur, James Hallam, Dr. Matthew Lewis, Chris Lock, Thomas Moehring, PhD, and Warren Potts Mass spectrometry continues to deliver gains in speed, sensitivity, and analytical depth.

Articles The habits that separate a two-minute fix from a two-hour hunt. A practical, senior-to-junior guide to diagnosing gas chromatography problems. Updated Written byCole Lapierre InterviewingMatthew Klee Google Gemini Every lab has one: the analyst who walks up to a misbehaving GC, glances at the chromatogram, checks two things, and has it running again before the kettle has boiled. That speed looks like instinct, but it rarely is.