Technology Networks

An unclear fungal identification can turn a routine environmental monitoring event into a longer investigation. Multiple matches, low-confidence results, and difficult-to-resolve molds can lead to repeat testing, external send-outs, and more time spent trying to reach an answer that is strong enough to support the next decision. The Applied Biosystems™ MicroSEQ™ ITS rDNA Fungal Identification Kit is designed to give laboratories greater resolution when that clarity matters.

Scientists at Queen Mary University of London have found a way to overcome cell’s natural defences against self-amplifying mRNA vaccines, thereby allowing them to produce significantly more of their target protein. The findings are published in Nature Communications. mRNA-based vaccines were central to getting us out of the Covid-19 pandemic.

Antibiotic resistance is supercharging dangerous gut bacteria to withstand even hospital-grade disinfectants intended to kill them. New research from Monash University, published in Nature Communications, reveals the bacteria Clostridioides difficile has picked up a key gene that gives its dormant spores a free pass against antibiotics and cleaning products. Its spores act like plant seeds, waiting patiently to activate and spread in the right environment, like the human gut.

Researchers at the Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital, Baylor College of Medicine, the Texome Project and collaborating institutions have identified variants in gene BRSK1 as a likely diagnosis for individuals with a rare and complex neurodevelopmental disorder who until now had not received an explanation for their condition. The study appears in the American Journal of Human Genetics.

Cell division is a complex process. At the heart of this complexity is a membrane-less organelle called the centrosome, which is made up of more than 200 components. It is responsible for the clustering of mitotic spindles, thread-like structures needed for separation of genetic material. Which parts of the centrosome are necessary and sufficient for this spindle assembly has long remained elusive.

What makes some antibodies more effective than others in driving tumor regression? We understand how an antibody works, but we are still trying to understand why binding to a target's surface with an antibody, even when it's very specific, often isn't sufficient. Individual tumors are differentially populated by different immune cells with distinct immune states.

Why does weight seem to come off easily for some people, while others struggle despite doing everything “right?” Mayo Clinic researchers may have just revealed part of the answer. In new research, published in Gastroenterology, three subtypes of obesity were identified. The subtypes may explain variable responses to glucagon-like peptide-1 (GLP-1) therapy.

More than 6 million U.S. homes have solar panels on their roofs — but what if you could generate power inside your house, too? Researchers from Binghamton University have developed a new type of wallpaper that turns moisture in the room into small amounts of electric current, and they hope to improve the technology for greater power yields. Professor Seokheun “Sean” Choi, a faculty member at the Thomas J.

A research team led by Profs. ZHANG Fan and GU Hongcang from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed HelixDTA, a deep learning model designed to improve drug-target affinity prediction. "The analysis helped us understand which parts of drugs and proteins are important for their interactions," ZHANG said. The findings were published in Journal of Chemical Information and Modeling.

The test can identify the genetic causes of many inherited muscle diseases in a single test. Read time: 2 minutes A new Garvan study, published in Nature Communications, outlined the development and application of the test to 53 Australians with known or suspected inherited muscle disease, including 31 whose previous genetic testing had failed to identify a cause. Over a third of those unsolved cases received a diagnosis through the new test.