The Limbic

New research findings support the use of aspirin monotherapy after hip or knee arthroplasty, with efficacy and bleeding outcomes comparable to a short course of rivaroxaban followed by aspirin. The study, presented at the International Society on Thrombosis and Haemostasis (ISTH) conference, found that aspirin alone was non-inferior to a five-day course of rivaroxaban followed by aspirin for preventing post-arthroplasty venous thromboembolism (VTE).

CPAP machines routinely under-report residual sleep apnoea, according to a US study that found standard device downloads missed most of the disease burden picked up by parallel physiological monitoring. The retrospective study, published in the journal Sleep [link here], analysed 24,939 nights of paired CPAP and physiological monitoring in 465 adults receiving PAP therapy through a single US telemedicine sleep practice.

Infant medulloblastoma can be stratified into molecular subtypes that vary widely in prognosis, paving the way for more targeted and less toxic therapies, new research has shown. One study identified DNA methylation-based subgroups of non-WNT/non-sonic hedgehog (SHH) medulloblastoma, with five-year progression-free survival (PFS) ranging from 64% to 0%.

Awareness of the importance of sex and gender issues in medical research may be increasing but evidence shows the issues are inconsistently addressed in study design, analysis, and interpretation of Australian cancer clinical trials. The findings of a study, published in Research Integrity and Peer Review [link here], suggest implementation of the Sex and Gender Equity in Research (SAGER) guidelines has been patchy.

Associate Professor Lucy Burr Australian bronchiectasis research has been recognised on the international stage, with respiratory physician and researcher Associate Professor Lucy Burr receiving one of the field’s leading honours for work spanning antibiotic stewardship, clinical trials and collaborative research. Associate Professor Burr received the Tobias Welte Award at the World Bronchiectasis Conference 2026.

One in five Australian patients with factor Xa inhibitor-related major bleeding die in hospital, with intracranial haemorrhage outcomes particularly poor regardless of the haemostatic strategy chosen, delegates at an international conference have heard.

Bladder cancer patients who were ctDNA negative before receiving adjuvant atezolizumab experience more immune-related adverse events (irAEs) without an apparent survival benefit, researchers report.

This brief video highlights the emerging treatment sotatercept, explaining how its novel mechanism of action significantly improves lung and heart function in PAH and discussing real world experience of telangiectasia in scleroderma patients treated with this agent. Professor Edmund Lau Senior Staff Specialist, Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney. Professor Jean Elwing Director of the Pulmonary Hypertension Program, University of Cincinnati, USA.

Cancer patients who develop a blood clot while on extended apixaban therapy face a very poor short-term prognosis, with half dying within weeks, a new analysis shows.

Australian researchers say surveillance could be a viable option for CDH1 carriers who have historically undergone gastrectomy due to their gastric cancer risk, amid data suggesting intramucosal lesions are more indolent than previously believed. However, the team, led by Melbourne gastroenterologist Professor Alex Boussioutas, has emphasised the need for appropriate counselling on the limitations of the approach and structured follow-up.