Trials Journal

The primary objective is to compare the therapeutic effects of IOT-BPEMFE and OT in patients with KOA, providing evidence to inform the selection of optimal community-based exercise delivery mode. The primary hypothesis is that IOT-BPEMFE will achieve pain and functional outcomes that are noninferior to those achieved with OT.

The CACE has been one of the most commonly applied statistical methods for handling non-compliance in RCTs [27]. Owing to its flexibility, CACE has been applied to various types of study designs and outcomes, including longitudinal studies with time-dependent non-compliance [28], and RCTs with univariate binary response [29], among others. In this paper, we propose a novel CACE-based method, LMI, to estimate treatment effects on continuous outcomes when there is substantial non-compliance.

The data will be collected in two stages, preintervention (T0) and postintervention at the end of the second month (T2), using the Depression Literacy Questionnaire (2014) [53]. This questionnaire consists of two parts: depression literacy and demographic characteristics: This section of the questionnaire pertains to the assessment of depression literacy and comprises 34 questions.

Study personnel follow patients throughout their time in the hospital before and after surgery and evaluate their clinical status and medical records, documenting all outcomes. Troponins are measured before surgery and on postoperative days 1, 2, and 3. An ECG is obtained whenever an elevated troponin is detected, as per routine practice. A heart ultrasound and/or cardiologist consultation is ordered as needed based on the investigator’s decision.

Crohn’s disease, marked by chronic gastrointestinal inflammation, presents challenges regarding management and due to recurrence of the disease. This study delves into the preventive potential of extended mesenteric excision in ileocecal resection to reduce disease recurrence in Crohn’s patients.

Correction: Development of a core outcome set for paediatric upper limb spasticity; a structured review protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey Correction Open access Published: 20 November 2025 Trials volume 26, Article number: 527 (2025) Cite this article The Original Article was published on 10 November 2025 Correction: Trials 26, 485 (2022) https://doi.org/10.1186/s13063-025-09141-w Following the publication of the...

Department of Physiotherapy and Department of Gynecology and Obstetrics, Srinivas Medical College Hospital, Mangalore, India. See Table 1. Not applicable, the study does not use any biological specimens or provisions for additional data. The comparators used in the study were chosen based on the study design, research question, and to match the objectives of the study. Control group (group A): Knack technique and Kegel’s exercises.

Correction: Elucidating treatment targets and mediators within a confirmatory efficacy trial: study protocol for a randomized controlled trial of cognitive-behavioral therapy vs.

Primary outcome: Elicited Imitation outcomes (number of steps correctly recalled and number of steps recalled in the correct order for both immediate and delayed recall) at age 15 months, i.e., after 9 months of daily supplementation with choline or placebo. For each of these outcomes, we will compare groups using a one-way analysis of covariance (ANCOVA).

Our study will be conducted at Al-Zahra Hospital, a large public, university-affiliated referral center for TBI in Isfahan, Iran.